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首页> 外文期刊>Eastern Journal of Medicine >Simple Peripheral Markers for Inflammation in Drug-Naive, Comorbidity-Free Adolescents with Obsessive?Compulsive Disorder
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Simple Peripheral Markers for Inflammation in Drug-Naive, Comorbidity-Free Adolescents with Obsessive?Compulsive Disorder

机译：单纯性外周标志物用于天真的，无合并症的强迫症青少年的炎症反应

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Simple Peripheral Markers for Inflammation in Drug-Naive, Comorbidity-Free Adolescents with Obsessive?Compulsive Disorder Halit Necmi U?arsup1/sup, Duygu Muratsup2/sup, ?afak Eray sup3/sup sup1/supDepartment of Child and Adolescent Psychiatry, Van Training and Research Hospital, Van, Turkey sup2/supDepartment of Child and Adolescent Psychiatry, Avc?lar Hospital, ?stanbul, Turkey sup3/supDepartment of Child and Adolescent Psychiatry, School of Medicine, University of Uludag INTRODUCTION: Obsessive Compulsive Disorder (OCD) is a psychiatric disorder which has different etiopathogenic mechanisms. One of these mechanisms is immunologic factors. Studies on immunologic factors, various cytokines and cellular elements were investigated. In order to evaluate the immunological factors in psychiatric disorders, a simple and inexpensive method, hemogram parameters have been investigated. We aimed to evaluate hemogram parameters in drug-naive, comorbidity-free adolescents with OCD comparing with controls. METHODS: A total of 31 patients diagnosed with OCD, who do not have comorbid diseases and do not take any medical therapy within the past one month, were included in the study. The control group consisted of 47 healthy subjects with no organic and psychiatric disorders. RESULTS: Lymphocytes, RDW, platelets, and PCT values of the adolescents with OCD were significantly lower than those of the control group. There were no differences between the two groups in terms of WBC, hemoglobin, RBC, HCT, MCV, MCH, MCHC, MPV, Neutrophils, neutrophil?lymphocyte ratio, and platelet-lymphocyte ratio. DISCUSSION AND CONCLUSION: The findings of the study reveal that lymphocytes and RDW tend to be lower in adolescents with OCD. The findings of our study are consistent with those of previous studies, indicating decreased hemogram parameters associated with inflammation in adolescents with OCD. Our study suggest that we need further study to fully understand the role of inflammation in the etiology and treatment of OCD, and follow-up studies should focus on the process of inflammation in psychiatric diseases in children and adolescents.
机译：单纯性外周标志物用于天真，无合并症，强迫症的青少年的炎症反应简单Halit Necmi U？ar 1 ，Duygu Murat 2 、? afak Eray 3 1 土耳其范市Van Training and Research Hospital儿童和青少年精神病学系 2 Avc？lar医院儿童和青少年精神病学系，？伊斯坦布尔，土耳其 3 乌鲁达大学医学院儿童和青少年精神病学系引言：强迫症（OCD）是一种精神病性疾病，其发病机制不同。这些机制之一是免疫因素。研究了免疫学因素，各种细胞因子和细胞因子的研究。为了评估精神疾病中的免疫学因素，已经研究了一种简单且便宜的方法，血象图参数。我们的目的是与对照相比，评估使用OCD的未使用过药物，无合并症的青少年的血流图参数。方法：共有31名被诊断为强迫症的患者在过去一个月内未合并疾病且未接受任何药物治疗。对照组由47名健康人组成，没有器质性和精神病性疾病。结果：OCD青少年的淋巴细胞，RDW，血小板和PCT值均显着低于对照组。两组之间在WBC，血红蛋白，RBC，HCT，MCV，MCH，MCHC，MPV，中性粒细胞，中性粒细胞淋巴细胞比率和血小板-淋巴细胞比率方面没有差异。讨论与结论：研究结果表明，强迫症青少年的淋巴细胞和RDW较低。我们的研究结果与以前的研究结果一致，表明与OCD青少年炎症相关的血流图参数降低。我们的研究表明，我们需要进一步研究，以充分了解炎症在强迫症的病因和治疗中的作用，后续研究应关注儿童和青少年精神疾病的炎症过程。

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