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Plasma cytokine abnormalities in drug-naive, comorbidity-free obsessive-compulsive disorder

机译：天真，无合并症强迫症的血浆细胞因子异常

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Growing evidence in the last decade suggest significant role of immune alterations in the pathogenesis of obsessive-compulsive disorder (OCD). Cytokines, mediators of inflammation, alter the neurotransmitter concentration and result in a hyposerotonergic and hyperglutamatergic state implicated in pathogenesis of OCD. However, only few studies have examined cytokine abnormalities in OCD with inconsistent results possibly due to confounding effects of medications and comorbid anxiety-depression. We examined 20 comorbidity free, drug free OCD patients and 20 age and sex matched healthy controls. Clinical severity was assessed using Yale Brown Obsessive Compulsive Scale, Hamilton anxiety rating scale, Hamilton depression rating scale and Clinical Global Impression. Levels of different cytokines, Interleukin (IL)-2, IL-4, IL-6, IL-10, Tumor necrosis factor (TNF)-alpha and Interferon (IFN)-gamma were assessed using Cytometric Bead Array. OCD patients had significantly greater plasma levels of IL-2, IL-4, IL-6, IL-10 and TNF-alpha levels than controls but not IFN-gamma. Reanalysis of data with only drug naive patients (excluding 4 drug free patients) did not alter the results. Presence of these abnormalities in drug-naive patients suggests the possible role of cytokines in the pathogenesis of OCD. Study findings have potential clinical utility in development of novel therapeutic options targeting cytokine aberrations in OCD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：在过去十年中，越来越多的证据表明免疫改变在强迫症（OCD）的发病机制中起着重要作用。细胞因子，炎症的介质，改变神经递质的浓度，并导致低血清素能和高谷氨酸能状态，与强迫症的发病有关。然而，只有很少的研究检查了强迫症中的细胞因子异常，结果不一致，可能是由于药物和合并焦虑症的混杂影响。我们检查了20名无合并症，无毒品的强迫症患者和20名年龄和性别匹配的健康对照。使用耶鲁·布朗强迫症量表，汉密尔顿焦虑量表，汉密尔顿抑郁量表和临床总体印象量表评估临床严重程度。使用细胞计数珠阵列评估不同细胞因子，白介素（IL）-2，IL-4，IL-6，IL-10，肿瘤坏死因子（TNF）-α和干扰素（IFN）-γ的水平。 OCD患者的血浆IL-2，IL-4，IL-6，IL-10和TNF-α水平明显高于对照组，但无IFN-γ。仅对单纯药物治疗患者（不包括4名无药物治疗的患者）进行的数据重新分析不会改变结果。在无药物治疗的患者中存在这些异常现象提示细胞因子可能在强迫症的发病机理中发挥作用。研究结果在开发针对OCD中细胞因子异常的新型治疗选择方面具有潜在的临床实用性。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

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