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首页> 外文期刊>Psychiatry research >Enhanced error related negativity amplitude in medication-naive, comorbidity-free obsessive compulsive disorder
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Enhanced error related negativity amplitude in medication-naive, comorbidity-free obsessive compulsive disorder

机译：增强误差相关的药物 - 幼稚，无合并症的强迫症振缩症

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摘要

Error monitoring and response inhibition is a key cognitive deficit in obsessive-compulsive disorder (OCD). Frontal midline regions such as the cingulate cortex and pre-supplementary motor area are considered critical brain substrates of this deficit. Electrophysiological equivalent of the above dysfunction is a fronto-central event related potential (ERP) which occurs after an error called the error related negativity (ERN). In this study, we sought to compare the ERN parameters between medication-naive, comorbidity-free subjects with OCD and healthy controls (HC). Age, sex and handedness matched subjects with medication-naive, comorbidity-free OCD (N = 16) and Healthy Controls (N = 17) performed a modified version of the flanker task while EEG was acquired for ERN. EEG signals were recorded from the electrodes FCz and Cz. Clinical severity of OCD was assessed using the Yale Brown Obsessive Compulsive Scale. The subjects with OCD had significantly greater ERN amplitude at Cz and FCz. There were no significant correlations between ERN measures and illness severity measures. Overactive performance monitoring as evidenced by enhanced ERN amplitude could be considered as a biomarker for OCD.
机译：错误监测和反应抑制是强迫症（OCD）中的关键认知缺陷。正面中线区域，如Cingulate Cortex和预补充电机区域被认为是这种赤字的关键脑基材。上述功能障碍的电生理等同物是在称为误差相关的消极性（ERN）的错误之后发生的前中心事件相关电位（ERP）。在这项研究中，我们试图将药物幼稚，无解受试者与OCD和健康对照（HC）进行比较。使用药物 - 幼稚，无共用的OCD（n = 16）和健康对照（n = 17）的年龄，性和混合匹配的受试者进行了一个修改版的Flanker任务，而EEG用于ERN。从电极FCZ和CZ记录EEG信号。使用耶鲁棕色强迫强迫尺度评估OCD的临床严重程度。 CZ和FCZ的OCD受试者具有明显更大的振幅。衡量措施和疾病严重程度措施之间没有显着相关性。通过增强的ERN幅度证明的过度活跃的性能监测可以被视为OCD的生物标志物。

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