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HIV-1 Reservoir Association with Immune Activation

机译:HIV-1储库与免疫激活

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In this issue of EBioMedicine, Ruggiero and colleagues describe immune activation biomarkers associated with the size of the HIV reservoir in a carefully designed cross-sectional study. The cohort consists of a homogeneous sample of HIV-1-infected patients with long-term plasma HIV-1 RNA suppression under antiretroviral treatment (ART). It is crucial to explore the potential utility of biomarkers that are easier (less labor intensive, less expensive) to measure than integrated HIV DNA load, in order to quickly and accurately quantify cellular reservoirs of HIV.
机译:在本期EBioMedicine中,Ruggiero及其同事在精心设计的横断面研究中描述了与HIV病毒库大小相关的免疫激活生物标记。该队列由在长期接受抗逆转录病毒治疗(ART)的血浆HIV-1 RNA抑制作用的HIV-1感染患者的同质样本组成。至关重要的是,探索生物标记物的潜在效用,这种标记物比整合的HIV DNA载量更易于测量(劳动强度低,成本低),以便快速准确地定量HIV细胞。

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