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首页> 外文期刊>EBioMedicine >Anthropogenic Carbon Nanotubes Found in the Airways of Parisian Children
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Anthropogenic Carbon Nanotubes Found in the Airways of Parisian Children

机译：在巴黎儿童气道中发现的人为碳纳米管

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Compelling evidence shows that fine particulate matters (PMs) from air pollution penetrate lower airways and are associated with adverse health effects even within concentrations below those recommended by the WHO. A paper reported a dose-dependent link between carbon content in alveolar macrophages (assessed only by optical microscopy) and the decline in lung function. However, to the best of our knowledge, PM had never been accurately characterized inside human lung cells and the most responsible components of the particulate mix are still unknown. On another hand carbon nanotubes (CNTs) from natural and anthropogenic sources might be an important component of PM in both indoor and outdoor air. We used high-resolution transmission electron microscopy and energy dispersive X-ray spectroscopy to characterize PM present in broncho-alveolar lavage-fluids (n=64) and inside lung cells (n=5 patients) of asthmatic children. We show that inhaled PM mostly consist of CNTs. These CNTs are present in all examined samples and they are similar to those we found in dusts and vehicle exhausts collected in Paris, as well as to those previously characterized in ambient air in the USA, in spider webs in India, and in ice core. These results strongly suggest that humans are routinely exposed to CNTs.
机译：有力的证据表明，来自空气污染的细颗粒物（PMs）渗透到下呼吸道，甚至在低于WHO推荐浓度的情况下也会对健康造成不利影响。一篇论文报道了肺泡巨噬细胞碳含量（仅通过光学显微镜评估）与肺功能下降之间的剂量依赖性联系。然而，据我们所知，人类肺细胞内部从未对PM进行准确的表征，而颗粒混合物中最负责任的成分仍然未知。另一方面，来自自然和人为来源的碳纳米管（CNT）可能是室内和室外空气中PM的重要成分。我们使用高分辨率透射电子显微镜和能量色散X射线光谱来表征哮喘儿童支气管肺泡灌洗液（n = 64）和肺细胞内（n = 5例患者）中的PM。我们显示，吸入的PM主要由CNT组成。这些碳纳米管存在于所有检查过的样品中，与我们在巴黎收集的灰尘和汽车尾气中发现的碳纳米管相似，并且与美国，印度的蜘蛛网和冰芯中以前以环境空气为特征的碳纳米管相似。这些结果强烈表明，人类通常会接触碳纳米管。

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