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首页> 外文期刊>EBioMedicine >Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2
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Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2

机译：由富含脯氨酸的酸性蛋白基因PRH1和PRH2定义的遗传和生活方式依赖性的龋齿

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Dental caries is a chronic infectious disease that affects billions of people with large individual differences in activity. We investigated whether PRH1 and PRH2 polymorphisms in saliva acidic proline-rich protein (PRP) receptors for indigenous bacteria match and predict individual differences in the development of caries. PRH1 and PRH2 variation and adhesion of indigenous and cariogenic ( Streptococcus mutans ) model bacteria were measured in 452 12-year-old Swedish children along with traditional risk factors and related to caries at baseline and after 5-years. The children grouped into low-to-moderate and high susceptibility phenotypes for caries based on allelic PRH1 , PRH2 variation. The low-to-moderate susceptibility children (P1 and P4a?) experienced caries from eating sugar or bad oral hygiene or infection by S. mutans . The high susceptibility P4a ( Db , PIF , PRP1 2 ) children had more caries despite receiving extra prevention and irrespective of eating sugar or bad oral hygiene or S. mutans -infection. They instead developed 3.9-fold more caries than P1 children from plaque accumulation in general when treated with orthodontic multibrackets; and had basic PRP polymorphisms and low DMBT1-mediated S. mutans adhesion as additional susceptibility traits. The present findings thus suggest genetic autoimmune-like (P4a) and traditional life style (P1) caries, providing a rationale for individualized oral care.
机译：龋齿是一种慢性传染病，影响数十亿个体活动差异很大的人。我们调查了唾液酸性富含脯氨酸的蛋白质（PRP）受体中本地细菌的PRH1和PRH2多态性是否匹配并预测了龋齿发展中的个体差异。在452名12岁的瑞典儿童中测量了PRH1和PRH2变异和黏附的本地和龋齿（变形链球菌）模型细菌以及传统的危险因素，并与基线和5年后的龋齿有关。根据等位基因PRH1，PRH2的变化，儿童将龋病分为低度至中度和高敏感性表型。低度至中度易感儿童（P1和P4a ？）因进食糖或口腔卫生不良或被变形链球菌感染而出现龋齿。高易感性P4a（Db，PIF，PRP1 2 ）儿童尽管接受了额外的预防，并且无论是否吃糖，不良的口腔卫生或变形链球菌感染，仍具有更多的龋齿。当使用正畸性多支架治疗时，他们的斑块堆积通常比P1儿童多出3.9倍的龋齿。并具有基本的PRP多态性和低DMBT1介导的变形链球菌粘附性，作为其他易感性状。因此，本研究结果提示遗传性自身免疫样（P4a）和传统生活方式（P1）龋齿，为个体化口腔护理提供了依据。

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