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首页> 外文期刊>EBioMedicine >Contrasting Pattern of Chronic Inflammatory Bowel Disease in Primary and Autoimmune Sclerosing Cholangitis
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Contrasting Pattern of Chronic Inflammatory Bowel Disease in Primary and Autoimmune Sclerosing Cholangitis

机译：原发性和自身免疫性硬化性胆管炎的慢性炎症性肠病的对比模式

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Background: Primary sclerosing cholangitis (PSC) and autoimmune sclerosing cholangitis (AISC) are related, but distinct chronic liver diseases. PSC is associated with a high prevalence of ulcerative colitis while the intestinal inflammation associated with AISC is less well characterised. Aims: To assess and contrast aspects of intestinal inflammation in patients with AISC and PSC and compare the clinical features with those of patients with ulcerative colitis and Crohn's disease. Methods: 23 and 22 patients with AISC and PSC, respectively, underwent review of colonoscopy and biopsy findings, capsule enteroscopy and assessment of clinical and inflammatory (faecal calprotectin) disease activity, which was compared with that of patients with ulcerative colitis and Crohn's disease (n=55 each). Findings: Five and 6 patients with AISC and PSC, respectively, had normal colonoscopy and faecal calprotectin levels of 34.4+/-8.3 and 39.7+/-8.4@mg/g, respectively (normal 0.05) between patients with intestinal inflammation in AISC (588+/-549@mg/g), PSC (421+/-351@mg/g), ulcerative colitis (501+/-656@mg/g) or Crohn's disease (476+/-571@mg/g). Capsule enteroscopy showed that 7 of 18 (39%) (p<0.03) of those with AISC had small bowel mucosal breaks whereas no patient with PSC had these findings. Interpretation: Collectively these findings lend support to the suggestion that the chronic inflammatory bowel disease associated with PSC and in particular AISC may represent a distinct nosologic entity different from classic ulcerative colitis and Crohn's disease.
机译：背景：原发性硬化性胆管炎（PSC）和自身免疫性硬化性胆管炎（AISC）是相关的，但与慢性肝病截然不同。 PSC与溃疡性结肠炎的高患病率有关，而与AISC相关的肠道炎症的特征则不太明确。目的：评估和对比AISC和PSC患者的肠道炎症状况，并将其与溃疡性结肠炎和克罗恩病患者的临床特征进行比较。方法：分别对23例和22例AISC和PSC患者进行结肠镜检查和活检，胶囊肠镜检查以及临床和炎性（粪便钙卫蛋白）疾病活性评估，并将其与溃疡性结肠炎和克罗恩病患者进行比较（ n = 55）。结果：AISC肠炎患者中，分别有5例和6例AISC和PSC患者的结肠镜检查和粪便钙卫蛋白水平正常，分别为34.4 +/- 8.3和39.7+/-8.4@mg/g（0.05）（正常） 588 +/- 549 @ mg / g），PSC（421 +/- 351 @ mg / g），溃疡性结肠炎（501 +/- 656 @ mg / g）或克罗恩氏病（476 +/- 571 @ mg / g） ）。胶囊肠镜检查显示，AISC患者中有18人中有7人（39％）（p <0.03）肠粘膜破裂小，而PSC患者中没有这些发现。解释：这些发现共同支持以下观点：与PSC尤其是AISC相关的慢性炎症性肠病可能代表与典型溃疡性结肠炎和克罗恩病不同的独特的病原学。

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