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首页> 外文期刊>Iranian Journal of Microbiology >A Study of prevalence of Shigella species and antimicrobial resistance patterns in paediatric medical center, Ahvaz, Iran
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A Study of prevalence of Shigella species and antimicrobial resistance patterns in paediatric medical center, Ahvaz, Iran

机译：伊朗阿瓦士儿童医学中心志贺氏菌的流行和耐药模式研究

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Background and Objectives: Shigella infections are one of the major causes of diarrhea worldwide, and especially in developing countries. Antimicrobial resistance has complicated the empirical treatment. The aim of this study was to define the clinical and antibiotic resistance patterns of Shigella gastroenteritis cases.Materials and Methods: Stool samples of patients with diarrhea and fever diagnosed with shigellosis were collected, from June 2013 to May 2014 at Abuzar Hospital, Iran. All samples were cultured for Shigella spp on selective and differential media. Shigella isolates were evaluated for antimicrobial resistance.Results: Among 193 Shigella isolates, S. flexneri (64.8%) was the predominant species followed by S. sonnei (32.6%). The most frequent antibiotic resistance observed, was towards co-trimoxazole (89%), ampicillin (77%) and ceftriaxone (51%) and the lowest resistance were seen in ciprofloxacin (1.5%), azithromycin (7%).Conclusion: Due to the high resistance to ceftriaxone, this drug is not recommended as an empirical therapy for shigellosis. However, azithromycin should be used as the first-line treatment for paediatric patients, suffering from shigellosis and ciprofloxacin can be used as an alternative.
机译：背景与目的：志贺氏菌感染是全世界腹泻的主要原因之一，尤其是在发展中国家。抗菌素耐药性使经验治疗变得复杂。本研究的目的是确定志贺氏肠胃炎病例的临床和抗生素耐药模式。材料与方法：2013年6月至2014年5月在伊朗阿布扎尔医院收集诊断为志贺氏菌病的腹泻和发烧患者的粪便样本。所有样品均在选择性和差异培养基上培养志贺氏菌。结果：在193株志贺氏菌中，以弗氏链球菌（64.8％）为主要菌种，其次是索内链球菌（32.6％）。观察到最常见的抗生素耐药性是对复方新诺明（89％），氨苄青霉素（77％）和头孢曲松（51％），环丙沙星（1.5％），阿奇霉素（7％）耐药性最低。由于对头孢曲松的高耐药性，不建议将该药物作为志贺菌病的经验疗法。但是，阿奇霉素应作为儿科患者的一线治疗，患有志贺菌病和环丙沙星可以替代。

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