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首页> 外文期刊>Iranian Journal of Neurology >Height, shape and anterior-posterior diameter of pituitary gland on magnetic resonance imaging among patients with multiple sclerosis compared to normal individuals
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Height, shape and anterior-posterior diameter of pituitary gland on magnetic resonance imaging among patients with multiple sclerosis compared to normal individuals

机译：与正常人相比，多发性硬化症患者磁共振成像下垂体的高度，形状和垂体前-后直径

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Background: Several studies indicate contribution of hypothalamus-pituitary-adrenal (HPA) axis in multiple sclerosis (MS) disease. This study was designed to determine whether there is an effective difference in pituitary height, shape, and anterior-posterior diameter (APD) between patients with MS and the control group.Methods: In this study, sagittal pituitary height and APD of 134 men and women (64 patients with MS and 70 healthy subjects as control group) were measured by T1 sequence magnetic resonance imaging (MRI). All the subjects were free of sellar or parasellar pathology without a history of surgical intervention or prolactin affecting drugs like bromocriptine and cabergoline or corticosteroid consumption.Results: Mean height of pituitary gland was 6.62 ± 1.43 and 5.78 ± 1.15 mm for patients and the control group, respectively, and the difference between the two groups was statistically significant (P = 0.001). Mean APD was 10.40 ± 1.29 mm for the group of patients and 10.25 ± 1.41 mm for the control group, respectively, without significant differences. 46.9%, 37.5%, and 15.6% of patients had flat, convex, and concave hypophyseal surfaces, respectively. This rate was 50%, 30%, and 20% among the control group, respectively. There was no significant difference between our measurements among patients on whom imaging study was performed at time of disease onset with others.Conclusion: Mean height of pituitary gland among patients with MS was significantly greater than the control group (P = 0.001). So can we consider the same etiology for pituitary hypertrophy among patients with MS as a hypothesis?
机译：背景：多项研究表明，下丘脑-垂体-肾上腺（HPA）轴在多发性硬化症（MS）疾病中的作用。本研究旨在确定MS患者与对照组之间垂体高度，形状和前后直径（APD）是否存在有效差异。方法：本研究中，有134名男性和男性的垂体垂体高度和APD通过T1序列磁共振成像（MRI）测量女性（64例MS患者和70例健康受试者为对照组）。所有受试者均无蝶鞍或鞍旁病变，无手术干预史或泌乳素影响药物如溴隐亭和卡麦角林或皮质类固醇的消耗。结果：患者和对照组的垂体平均高度分别为6.62±1.43和5.78±1.15 mm ，两组之间的差异具有统计学意义（P = 0.001）。患者组的平均APD为10.40±1.29 mm，对照组的平均APD为10.25±1.41 mm，无显着差异。分别有46.9％，37.5％和15.6％的患者的垂体表面平坦，凸出和凹入。在对照组中，该比率分别为50％，30％和20％。在与其他疾病发作时进行影像学检查的患者之间，我们的测量值之间无显着差异。结论：MS患者的垂体平均高度明显高于对照组（P = 0.001）。那么，我们是否可以将MS患者垂体肥大的病因视为假设呢？

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