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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Comparing effects of interleukin-2 and interleukin-4 on the expression of MHC class II, CD80 and CD86 on polymorphonuclear neutrophils
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Comparing effects of interleukin-2 and interleukin-4 on the expression of MHC class II, CD80 and CD86 on polymorphonuclear neutrophils

机译：白细胞介素2和白细胞介素4对多形核中性粒细胞MHC II类，CD80和CD86表达的影响比较

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Polymorphonuclear neutrophils (PMN) have contributed only to the innate immune response, due to their phagocytosis activity. They have a short life time. Some studies of PMN cytokine production and expression of numerous cell surface proteins have suggested that PMN are likely to influence adaptive responses and may satisfy the criteria of antigen presenting cells. Flow cytometry was used in the present study for the detection of cell surface major histocompatibility complex (MHC) class II, CD80 and CD86 required for antigen presentation and subsequent T-cell activation. Human peripheral blood neutrophils were used for this purpose. In vitro stimulation of PMN with IL-2 or IL-4 for 24h showed expression of MHC class II, CD80 and CD86. These observations, therefore, provide support to the hypothesis that human PMN have the potential to express molecules required for antigen presentation.
机译：多形核中性粒细胞（PMN）由于其吞噬作用而仅对先天免疫应答起作用。他们的寿命很短。对PMN细胞因子产生和许多细胞表面蛋白表达的一些研究表明，PMN可能会影响适应性反应并可能满足抗原呈递细胞的标准。在本研究中使用流式细胞仪检测抗原呈递和随后的T细胞活化所需的细胞表面主要组织相容性复合物（MHC）II类，CD80和CD86。人类外周血中性粒细胞用于此目的。用IL-2或IL-4体外刺激PMN 24h显示出MHC II类，CD80和CD86的表达。因此，这些发现为人PMN具有表达抗原呈递所需分子的潜力的假设提供了支持。

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