• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Risk factors for autism: An Egyptian study
【24h】

Risk factors for autism: An Egyptian study

机译：自闭症的危险因素：一项埃及研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study has been conducted to determine the possible risk factors of autism. This case control study was conducted at pediatric hospital, Ain Shams University on, 100 autistic patients who were subjected to the followings tools: Confirmation of diagnosis using DSM-IV-TR criteria, IQ assessment using Stanford–Binrent intelligence scale, and assessment of severity of autistic symptoms using childhood autism rating scale (CARS). Full clinical examination, neurological examination, EEG and audiological assessment were also done. Forty-six percent of our patients with autistic symptoms presented at the age of one and half years and 32% at the age of 2years. Fifty-five percent of our patients had mild to severe retardation (IQ=20–70), 36% below average mentality (IQ=71–89) and 9% with normal mentality (IQ=90–109). High maternal age (mother, ?35years) at birth was found in 23% of autistic children in comparison to 9.5% of controls. Also advanced paternal age (father, ?35years) at birth was found in 91% of cases in comparison to 83.5% of control group and the difference was statistically significant. Positive family history was found to be statistically significantly associated with the risk of autism (16% of cases versus 1% of control). All studied developmental milestones were delayed among autistic children than control group ( p =0.000). As regards natal factors, a history of low birth weight, delivery by ceserian section were significantly higher among cases than controls. Also postnatal factors as history of hypoxia, resuscitation and history of jaundice were considered significantly risk factors for autism ( p =0.000).
机译：进行了这项研究以确定自闭症的可能危险因素。该病例对照研究在Ain Shams大学的儿科医院进行，研究对象为100名自闭症患者，他们接受以下工具：使用DSM-IV-TR标准确认诊断，使用Stanford-Binrent智能量表进行智商评估以及严重程度评估儿童自闭症评分量表（CARS）对自闭症症状的评估。还进行了全面的临床检查，神经系统检查，脑电图和听觉评估。在我们的自闭症患者中，有46％在1岁半时出现，在2岁时有32％出现。我们的患者中有55％患有轻度至重度智力低下（IQ = 20–70），低于平均心智水平（IQ = 71–89）36％和9％正常心智（IQ = 90–109）。自闭症儿童中有23％的婴儿出生时母亲年龄高（母亲35岁），对照组为9.5％。与对照组的83.5％相比，在91％的病例中也发现了父亲的高龄（父亲，≥35岁），差异具有统计学意义。发现阳性家族史与自闭症风险在统计学上显着相关（16％的病例与1％的对照）。自闭症儿童的所有研究发展里程碑均较对照组延迟（p = 0.000）。关于出生因素，病例中低出生体重史，剖宫产分娩史明显高于对照组。出生后缺氧，复苏和黄疸病史等因素也被认为是自闭症的重要危险因素（p = 0.000）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号