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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Serum interferon-alpha level in first degree relatives of systemic lupus erythematosus patients: Correlation with autoantibodies titers
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Serum interferon-alpha level in first degree relatives of systemic lupus erythematosus patients: Correlation with autoantibodies titers

机译：系统性红斑狼疮患者一级亲属的血清干扰素-α水平：与自身抗体滴度的相关性

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Background and objectives Interferon-α (IFN-α), a cytokine with both antiviral and immune-regulatory functions, was suggested as a useful tool which can evaluate current systemic lupus erythematosus (SLE) disease activity and identify patients who are at risk of future disease flares. In the current study, serum IFN-α levels and associated demographic, and serological features in Egyptian SLE patients and their first degree relatives (FDRs) in comparison to unrelated healthy controls (UHCs) were examined, in order to identify individuals at the greatest risk for clinical illness. Methods In a cross-sectional study, blood samples were drawn from 54 SLE patients, 93 of their FDRs who consented to enroll into the study and 76 UHCs. Measurement of serum IFN-α by a modified ELISA was carried out. Data were analyzed for associations of serum IFN-α levels with autoantibodies titer. Results Mean serum IFN-α in FDRs was statistically higher than the UHCs and lower than in SLE patients ( P <0.0001) and it was correlated with ANA titer ( r =0.6, P <0.0001) and anti ds DNA titer ( r =0.62, P <0.0001). Conclusion IFN-α is a crucial player in the complicated autoimmune changes that occur in SLE and serum IFN-α can be a useful marker identifying persons who are at risk of future disease development.
机译：背景和目的干扰素-α（IFN-α）是一种具有抗病毒和免疫调节功能的细胞因子，被认为是一种有用的工具，可以评估当前的系统性红斑狼疮（SLE）疾病活动并确定有未来风险的患者疾病爆发。在当前的研究中，检查了埃及SLE患者及其一级亲属（FDR）与无关健康对照（UHCs）相比的血清IFN-α水平以及相关的人口统计学和血清学特征，以鉴定风险最大的个体用于临床疾病。方法在一项横断面研究中，从54名SLE患者，93名同意参加该研究的FDR和76名UHC中抽取血液。通过改良的ELISA测定血清IFN-α。分析了血清IFN-α水平与自身抗体滴度的相关性。结果FDRs中的平均血清IFN-α在统计学上高于UHCs，低于SLE患者（P <0.0001），并且与ANA滴度（r = 0.6，P <0.0001）和抗ds DNA滴度（r = 0.62）相关。 ，P <0.0001）。结论IFN-α是SLE中复杂的自身免疫变化的关键因素，血清IFN-α可以作为识别有未来疾病风险的人的有用标记。

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