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Genetics of obesity

机译:肥胖的遗传学

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There is now widespread recognition that the continuing increase in the prevalence of obesity seen in many countries is likely to have major adverse effects on public health. The National Center for Health Statistics reports that 61% of adults in the United States are overweight and 26% are obese. Also The National Health and Nutrition Examination Survey IV, 1999–2002, documents that 16% of children are overweight and 31% are at risk of becoming overweight or are already overweight, representing nearly a 300% increase since the 1960s. The genetic influences are likely to be particularly powerful in people with severe and early-onset obesity, the group is most likely to suffer adverse clinical consequences. In this review we will discuss the Genetics of body weight regulation including genes encoding factors regulating food/energy intake, genes encoding factors implicated in energy expenditure, and genes encoding factors implicated in adipogenesis as well as syndromic forms of obesity.
机译:现在,人们普遍认识到,在许多国家中,肥胖症患病率的持续增加可能对公共卫生产生重大不利影响。国家卫生统计中心的报告显示,美国61%的成年人超重,而26%的肥胖。此外,1999-2002年的《美国国家健康和营养检查调查IV》还记录了16%的儿童超重,而31%的儿童有超重或已经超重的危险,自1960年代以来增长了近300%。遗传影响在患有严重和早发性肥胖症的人中可能特别强大,该群体最有可能遭受不利的临床后果。在这篇综述中,我们将讨论体重调节的遗传学,包括编码调节食物/能量摄入的因子的基因,编码与能量消耗有关的因子的基因,编码与脂肪形成以及肥胖的症状形式有关的因子的基因。

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