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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >A study on the association of TCF7L2 rs11196205 (C/G) and CAPN10 rs3792267 (G/A) polymorphisms with type 2 diabetes mellitus in the South Western of Iran
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A study on the association of TCF7L2 rs11196205 (C/G) and CAPN10 rs3792267 (G/A) polymorphisms with type 2 diabetes mellitus in the South Western of Iran

机译：伊朗西南部TCF7L2 rs11196205（C / G）和CAPN10 rs3792267（G / A）多态性与2型糖尿病的相关性研究

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Background Type 2 diabetes mellitus is a multifactorial and heterogenic disease with a complex etiology. In recent decades the association of a large number of genes has been shown with T2DM. CAPN10 gene was the first T2DM candidate gene identified through genome-wide screening and positional cloning, and among all identified genes until now, TCF7L2 gene has shown most association with T2DM. The aim of this study was to investigate the association between TCF7L2 rs11196205(C/G) and CAPN10 rs3792267 (G/A) with T2DM in a subset of Iranian population from Khuzestan province. It should be noted that this is the first report of TCF7L2 polymorphism rs11196205with T2DM in Iran. Subjects and methods A case-control association study was performed using 150 T2DM patients and 150 controls. Genotyping for TCF7L2 rs11196205 was done by Tetra-Primer ARMS-PCR and for CAPN10 rs3792267 was done by PCR-RFLP Technique. Results Statistical analyses were carried out using SPSS version 16. In examining TCF7L2 rs11196205 based on the genotype GG, results for CG genotype were, 95%CI?=?(0.5–1.7), OR?=?0.92, P-value?=?0.79 and for genotype CC were, 95%CI?=?(0.94–3.92), OR?=?1.92, P-value?=?0.07. in examining CAPN10 rs3792267 based on the genotype AA, results for GG genotype were, 95%CI?=?(0.55–6.8), OR?=?1.93, P-value?=?0.31 and for genotype GA were, 95%CI?=?(0.43–5.64), OR?=?1.55, P-value?=?0.5. So, in both polymorphisms, none of the alleles or genotypes had significant statistical differences between case and control groups (P?>?0.05). Conclusion Our results showed that TCF7L2 rs11196205 and CAPN10 rs3792267 (SNP- 43) polymorphisms are not associated with the risk of T2DM in the studied population.
机译：背景技术2型糖尿病是一种病因复杂的多因素异质性疾病。在最近的几十年中，已经证明大量基因与T2DM的关联。 CAPN10基因是通过全基因组筛选和位置克隆鉴定的第一个T2DM候选基因，在所有已鉴定的基因中，迄今为止，TCF7L2基因显示出与T2DM的关联最多。这项研究的目的是调查Khuzestan省一部分伊朗人口中TCF7L2 rs11196205（C / G）和CAPN10 rs3792267（G / A）与T2DM的关联。应当指出的是，这是TCF7L2多态性rs11196205与T2DM的首次报道。受试者和方法使用150名T2DM患者和150名对照进行了病例对照研究。使用Tetra-Primer ARMS-PCR对TCF7L2 rs11196205进行基因分型，对PCR的RFLP技术对CAPN10 rs3792267进行基因分型。结果使用SPSS版本16进行统计分析。在检查基于GG基因型的TCF7L2 rs11196205时，CG基因型的结果为95％CI≥=（0.5-1.7），OR≥= 0.92，P值≥ 0.79和基因型CC分别为95％CI？=？（0.94-3.92），OR？=？1.92，P值？=？0.07。根据AA基因型检查CAPN10 rs3792267时，GG基因型的结果为95％CI？=？（0.55-6.8），OR？=？1.93，P值？=？0.31，而GA基因型的结果为95％CI ？=？（0.43-5.64），或？== 1.55，P值？=？0.5。因此，在这两个多态性中，病例组和对照组之间的等位基因或基因型均无统计学差异（P≥0.05）。结论我们的结果表明，在研究人群中TCF7L2 rs11196205和CAPN10 rs3792267（SNP-43）多态性与T2DM的风险无关。

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