Antihistamines are a group of medications which can inhibit various histaminic actions at one of two histamine receptors (H 1 or H 2 ). H 1 receptor antagonists are used for the relief of allergic dermatological and nondermatological conditions. We will review classes of antihistamines (H 1 antagonists) and the relationship between specific antihistamines and specific birth defects. Although many findings provide reassurance about the relative safety of many antihistamine drugs and that any malformation reported is most probably caused by chance, studies are still required to assure fetal safety. As pruritus is sometimes troublesome for pregnant women topical medications like emollients should be tried first in the first trimester of pregnancy. Also pregnant women should be advised to consult their health care provider before taking any medication.
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机译：抗组胺药是一组药物，可以抑制两种组胺受体（H 1或H 2）之一的各种组织学作用。 H 1受体拮抗剂用于缓解过敏性皮肤病和非皮肤病。我们将审查抗组胺药（H 1拮抗剂）的种类以及特定抗组胺药与特定出生缺陷之间的关系。尽管许多发现为许多抗组胺药的相对安全性提供了保证，并且所报道的任何畸形最有可能是偶然造成的，但仍需要进行研究以确保胎儿安全。由于瘙痒有时会给孕妇带来麻烦，因此应在怀孕的前三个月首先尝试使用局部药物（如润肤剂）。另外，应建议孕妇在服用任何药物之前咨询其保健提供者。
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