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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >Association of glutathione-S-transferase P1 (GSTP1)-313 A G gene polymorphism and susceptibility to endometrial hyperplasia among Egyptian women
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Association of glutathione-S-transferase P1 (GSTP1)-313 A G gene polymorphism and susceptibility to endometrial hyperplasia among Egyptian women

机译：谷胱甘肽-S-转移酶P1（GSTP1）-313的关联 A G 基因多态性与埃及女性子宫内膜增生的易感性

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Background Endometrial hyperplasia (EH) occurs when the endometrium, the lining of the uterus, becomes too thick, causing abnormal uterine bleeding. In some cases, it can lead to endometrial carcinoma if untreated. Glutathione-S-transferases (GSTs) enzymes have a role in the metabolism of a lot of disease-causing carcinogens and mutagens that are present in environments of human. GSTP 1–313 A G gene polymorphism was associated with significantly high risk of endometrial carcinoma in some reports. The aim of this work is to assess the association of this polymorphism with the susceptibility of EH among a sample of Egyptian women. Subjects and methods This study included 84 unrelated EH Egyptian women who were compared to 134 healthy controls from the same locality. For all subjects, DNA was genotyped for GSTP 1–313 A G ( Ile105Val ) polymorphism using the PCR–RFLP technique. Results The frequency of GSTP 1–313 AG and GG genotypes was noted to be significantly higher among most of the cases with EH compared to controls (79.8% vs . 42.0%, OR = 8.63, 95% CI = 4.53–16.46, p 0.001). Also the frequency of the GSTP 1–313 G allele was significantly higher among most of the cases compared to controls (24.9% vs . 16.8%, OR = 3.72, 95% CI = 2.39–5.79, p 0.001). Furthermore, there was a significant increase of endometrial thickness in the EH women compared to controls ( p 0.001). Conclusions GSTP 1–313 G allele carriage was associated with susceptibility of EH among a sample of Egyptian women.
机译：背景当子宫内膜子宫内膜变得太厚，导致子宫异常出血时，就会发生子宫内膜增生（EH）。在某些情况下，如果不治疗，可能导致子宫内膜癌。谷胱甘肽-S-转移酶（GST）酶在人类环境中存在的许多致病性致癌物和诱变剂的代谢中起作用。 GSTP 1–313 A> G基因多态性与子宫内膜癌的高风险有关。这项工作的目的是评估埃及妇女样本中这种多态性与EH易感性的关系。对象和方法这项研究纳入了84名无关的EH埃及妇女，并与来自同一地区的134名健康对照者进行了比较。对于所有受试者，使用PCR-RFLP技术对GSTP 1–313 A> G（Ile105Val）多态性的DNA进行基因分型。结果在大多数EH病例中，GSTP 1–313 AG和GG基因型的频率显着高于对照组（79.8％vs. 42.0％，OR = 8.63，95％CI = 4.53–16.46，p < 0.001）。在大多数情况下，GSTP 1–313 G等位基因的频率也显着高于对照组（24.9％vs. 16.8％，OR = 3.72，95％CI = 2.39–5.79，p <0.001）。此外，与对照组相比，EH妇女的子宫内膜厚度明显增加（p <0.001）。结论GSTP 1–313 G等位基因携带与埃及女性样本中EH易感性有关。

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