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首页> 外文期刊>Iranian Journal of Reproductive Medicine >COMPARING CLOMIPHEN CITRATE PLUS HMG WITH CLOMIPHEN CITRATE PLUS RFSH IN IUI CYCLES IN COUPLES WITH UNEXPLAINED ORMALE FACTOR INFERTILITY: A PROSPECTIVE RANDOMIZED STUDY
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COMPARING CLOMIPHEN CITRATE PLUS HMG WITH CLOMIPHEN CITRATE PLUS RFSH IN IUI CYCLES IN COUPLES WITH UNEXPLAINED ORMALE FACTOR INFERTILITY: A PROSPECTIVE RANDOMIZED STUDY

机译：IOM循环中柠檬酸柠檬酸加HMG与柠檬酸柠檬酸加FSH的比较，男性配偶因素不明：预期的随机研究

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Background: Different protocols are used for controlled ovarian hyper stimulation (COH), but the optimal method has not yet been determined.Objective: The aim of this study was to compare the outcome of controlled ovarian stimulation (COS) using clomiphen citrate (CC) plus HMG versus CC plus rFSH in intra uterine insemination cycles (IUI). Materials and Methods: 144 women with unexplained or male factor infertility undergoing IUI cycles were randomized (72 patients in CC plus rFSH group and 72 patients in CC plus HMG group) and included in this single blind study from October 2006 to June 2010. The primary outcomes were clinical and ongoing pregnancy rates. The number of dominant follicles, mean of follicular size, endometrial thickness on the day of HCG administration, total dose of gonadotropins and duration of stimulation with gonadotropins were secondary outcomes. Results: Clinical and ongoing pregnancy rates were not significantly different in the two groups .There was a significant higher multiple pregnancy rate in CC plus rFSH group (33.3%) versus CC plus HMG group (12.5%; p0.005). There were no statistically significant differences in the secondary outcomes between the two groups.Conclusion: According to our results it seems that CC plus HMG is a more suitable and cost-effective regimen than CC plus rFSH in IUI cycles in patients with unexplained or male factor infertility.
机译：背景：控制性卵巢过度刺激（COH）使用了不同的方案，但尚未确定最佳方法。目的：本研究的目的是比较柠檬酸克罗米酚（CC）对控制性卵巢刺激（COS）的结果。子宫内授精周期（IUI）中，HMG与CC以及rFSH进行比较。材料与方法：随机将144例经IUI循环治疗的原因不明或男性不育的女性（CC + rFSH组72例，CC + HMG组72例）随机分组，并纳入2006年10月至2010年6月的单盲研究。结果是临床和持续妊娠率。次要结果是主要的卵泡数量，卵泡大小平均值，HCG注射当天的子宫内膜厚度，促性腺激素的总剂量和促性腺激素刺激的持续时间。结果：两组的临床和持续妊娠率无显着差异.CC + rFSH组（33.3％）显着高于CC + HMG组（12.5％; p <0.005）。两组之间的次要结局在统计学上无显着差异。结论：根据我们的研究结果，对于原因不明或男性因素的IUI周期，CC + HMG似乎比CC + rFSH更合适且更具成本效益。不孕症。

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