...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>EFSA Journal >Scientific opinion on the risks for animal and human health related to the presence of quinolizidine alkaloids in feed and food, in particular in lupins and lupin‐derived products
【24h】

Scientific opinion on the risks for animal and human health related to the presence of quinolizidine alkaloids in feed and food, in particular in lupins and lupin‐derived products

机译：关于饲料和食品中特别是羽扇豆和羽扇豆制品中喹喔啉生物碱的存在对动物和人类健康风险的科学见解

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The European Commission asked EFSA for a scientific opinion on the risks for animal and human health related to the presence of quinolizidine alkaloids (QAs) in feed and food. This risk assessment is limited to QAs occurring in Lupinus species/varieties relevant for animal and human consumption in Europe (i.e. Lupinus albus L., Lupinus angustifolius L., Lupinus luteus L. and Lupinus mutabilis Sweet). Information on the toxicity of QAs in animals and humans is limited. Following acute exposure to sparteine (reference compound), anticholinergic effects and changes in cardiac electric conductivity are considered to be critical for human hazard characterisation. The CONTAM Panel used a margin of exposure (MOE) approach identifying a lowest single oral effective dose of 0.16 mg sparteine/kg body weight as reference point to characterise the risk following acute exposure. No reference point could be identified to characterise the risk of chronic exposure. Because of similar modes of action for QAs, the CONTAM Panel used a group approach assuming dose additivity. For food, the highest mean concentration of Total QAs (TotQAs) (i.e. the 6 most abundant QAs) was found in lupin seed samples classified as ‘Lupins (dry) and similar‐’. Due to the limited data on occurrence and consumption, dietary exposure was calculated for some specific scenarios and no full human health risk characterisation was possible. The calculated margin of exposures (MOEs) may indicate a risk for some consumers. For example, when lupin seeds are consumed without a debittering step, or as debittered lupin seeds high in QA content and when ‘lupin‐based meat imitates’ are consumed. For horses, companion and farm animals, other than salmonids, the available database on adverse effects was too limited to identify no‐observed‐adverse‐effect levels and/or lowest‐observed‐adverse‐effect levels and no risk characterisation was possible. For salmonids, the CONTAM Panel considers the risk for adverse effects to be low.
机译：欧盟委员会要求欧洲食品安全局（EFSA）就饲料和食品中喹喔啉生物碱（QAs）的存在对动物和人类健康的风险提出科学意见。这项风险评估仅限于在欧洲与动物和人类食用有关的羽扇豆物种/变种中发生的QA（即羽扇豆，羽扇豆，黄羽扇豆和甜羽扇豆）。有关QA对动物和人类毒性的信息有限。急性接触斯巴地丁（参考化合物）后，抗胆碱能作用和心脏电导率的变化被认为对表征人类危害至关重要。 CONTAM小组使用暴露裕度（MOE）方法确定了0.16毫克黄柏碱/千克体重的最低单次口服有效剂量作为参考点，以表征急性暴露后的风险。无法确定参考点来表征慢性暴露的风险。由于QA的作用方式相似，因此CONTAM专家组采用了假定剂量加和的分组方法。对于食品，在羽扇豆种子样品中发现的总QAs（TotQAs）最高平均浓度（即6个最丰富的QAs）是“羽扇豆（干）和类似品”。由于有关发生和消费的数据有限，因此针对某些特定情况计算了饮食摄入量，无法全面描述人类健康风险。计算得出的风险敞口幅度（MOE）可能表明某些消费者存在风险。例如，当食用没有羽化步骤的羽扇豆种子时，或者当QA含量高的羽化羽扇豆种子时，以及食用“基于羽扇豆的肉制品”时。对于马，伴侣动物和农场动物（鲑鱼除外），可用的不良影响数据库太有限，无法识别未观察到的不良反应水平和/或观察到的最低不良反应水平，因此无法进行风险表征。对于鲑鱼，CONTAM专家组认为不良影响的风险较低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号