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首页> 外文期刊>Endocrine Connections >Vitamin D, carotid intima–media thickness and bone structure in patients with type 2 diabetes
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Vitamin D, carotid intima–media thickness and bone structure in patients with type 2 diabetes

机译：2型糖尿病患者的维生素D，颈动脉内膜中层厚度和骨结构

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Despite aggressive treatment of cardiovascular disease (CVD) risk factors individuals with type 2 diabetes (T2D) still have increased risk of cardiovascular morbidity and mortality. The primary aim of this study was to examine the cross-sectional association between total (25-hydroxy vitamin D (25(OH)D)) and risk of CVD in patients with T2D. Secondary objective was to examine the association between 25(OH)D and bone health. A Danish cohort of patients with T2D participating in a randomised clinical trial were analysed. In total 415 patients (68% men, age 60±9 years (mean± s.d .), duration of diabetes 12±6 years), including 294 patients (71%) treated with insulin. Carotid intima–media thickness (IMT) and arterial stiffness (carotid artery distensibility coefficient (DC) and Young's elastic modulus (YEM)) were measured by ultrasound scan as indicators of CVD. Bone health was assessed by bone mineral density and trabecular bone score measured by dual energy X-ray absorptiometry. In this cohort, 214 patients (52%) were vitamin D deficient (25(OH)D <50?nmol/l). Carotid IMT was 0.793±0.137?mm, DC was 0.0030±0.001?mmHg, YEM was 2354±1038?mmHg and 13 (3%) of the patients were diagnosed with osteoporosis. A 25(OH)D level was not associated with carotid IMT or arterial stiffness ( P >0.3) or bone health ( P >0.6) after adjustment for CVD risk factors. In conclusion, 25(OH)D status was not associated with carotid IMT, arterial stiffness or bone health in this cohort of patients with T2D. To explore these associations and the association with other biomarkers further, multicentre studies with large numbers of patients are required.
机译：尽管积极地治疗了心血管疾病（CVD）危险因素，但2型糖尿病（T2D）个体的心血管疾病发病率和死亡率仍然较高。这项研究的主要目的是检查T2D患者的总（25-羟基维生素D（25（OH）D））与CVD风险之间的横断面联系。次要目标是检查25（OH）D与骨骼健康之间的关系。分析了参加随机临床试验的丹麦T2D患者队列。在总共415例患者中（68％的男性，年龄60±9岁（平均±s.d.），糖尿病持续时间12±6年），其中294例（71％）接受了胰岛素治疗。通过超声扫描测量颈动脉内膜中层厚度（IMT）和动脉僵硬度（颈动脉扩张系数（DC）和杨氏弹性模量（YEM））作为CVD的指标。通过骨矿物质密度和通过双能X线骨密度仪测量的小梁骨评分来评估骨骼健康。在该队列中，有214名患者（52％）缺乏维生素D（25（OH）D <50？nmol / l）。颈动脉IMT为0.793±0.137？mm，DC为0.0030±0.001？mmHg，YEM为2354±1038？mmHg，其中13例（3％）被诊断出患有骨质疏松症。调整CVD危险因素后，25（OH）D水平与颈动脉IMT或动脉僵硬度（P> 0.3）或骨骼健康（P> 0.6）不相关。总之，在这一队列的T2D患者中，25（OH）D状态与颈动脉IMT，动脉僵硬度或骨骼健康无关。为了进一步探索这些关联以及与其他生物标记的关联，需要对大量患者进行多中心研究。

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