Recipes for Making Human Interneurons from Stem Cells Require Multiple Factors, Careful Timing, and Long Maturation Periods

Elizabeth M. Powell

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Recipes for Making Human Interneurons from Stem Cells Require Multiple Factors, Careful Timing, and Long Maturation Periods

机译：从干细胞制备人间神经元的配方需要多种因素，谨慎的时机和较长的成熟期

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In conclusion, the groups led by Kriegstein and Studer have overcome several of the hurdles in generating GABA interneurons for use in human therapies. Previous methods were unable to generate sufficient numbers of replacement cells for transplantation into patients or preclinical drug testing applications. The methods described by Kriegstein and Studer can produce substantial fractions of specific neurons that are capable of maturing into neurons with characteristics that approach adult cells, representing a major step in translating stem cell biology into regenerative medicine.

机译：总之，由Kriegstein和Studer领导的小组克服了产生用于人体疗法的GABA中间神经元的几个障碍。先前的方法无法产生足够数量的替代细胞用于移植到患者体内或临床前药物测试应用中。 Kriegstein和Studer描述的方法可以产生相当一部分特定的神经元，这些神经元能够成熟为具有接近成年细胞特征的神经元，这是将干细胞生物学转化为再生医学的重要一步。

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《Epilepsy currents》 |2013年第6期|共页
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Elizabeth M. Powell;
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中图分类神经病学与精神病学;
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1. Recipes for making human interneurons from stem cells require multiple factors, careful timing, and long maturation periods [J] . PowellE.M. Epilepsy currents . 2013,第6期

机译：从干细胞制备人间神经元的配方需要多种因素，谨慎的时机和较长的成熟期
2. Recipes for Making Human Interneurons from Stem Cells Require Multiple Factors, Careful Timing, and Long Maturation Periods [J] . Elizabeth M. Powell Epilepsy currents . 2013,第6期

机译：从干细胞制备人间神经元的配方需要多种因素，谨慎的时机和较长的成熟期
3. Orthodenticle is required for the development of olfactory projection neurons and local interneurons in Drosophila Orthodenticle is required for the development of olfactory projection neurons and local interneurons in Drosophila Orthodenticle is required for the development of olfactory projection neurons and local interneurons in Drosophila [J] . K. VijayRaghavan, Sonia Sen, Heinrich Reichert, Biology Open . 2014,第8期

机译：在果蝇中，嗅觉投射神经元和局部中间神经元的发育需要齿科。在果蝇中，嗅觉投射神经元和局部中间神经元的发育需要齿科
4. Atmospheric pressure plasma treatment increases the attachment and maturation of human pluripotent stem cell derived retinal pigment epithelial cells on biodegradable polymeric electrospun scaffolds [C] . A. Sorkio, P. Porter, K. Juuti-Uusitalo, 26th European conference on biomaterials 2014 . 2014

机译：大气压等离子体处理可增强人多能干细胞衍生的视网膜色素上皮细胞在可生物降解的聚合物电纺丝支架上的附着和成熟
5. Genetic factors involved in the generation and maturation of interneuron diversity within the developing mouse telencephalon. [D] . Batista-Brito, Renata. 2010

机译：发育中的小鼠端脑内神经元多样性的产生和成熟的遗传因素。
6. Recipes for Making Human Interneurons from Stem Cells Require Multiple Factors Careful Timing and Long Maturation Periods [O] . Elizabeth M. Powell 2013

机译：从干细胞制备人间神经元的食谱需要多种因素谨慎的时机和较长的成熟期
7. Recipes for Making Human Interneurons from Stem Cells Require Multiple Factors, Careful Timing, and Long Maturation Periods [O] . Elizabeth M. Powell 2013

机译：从干细胞制作人类细胞核的食谱需要多种因素，仔细时序和长达时间

Recipes for Making Human Interneurons from Stem Cells Require Multiple Factors, Careful Timing, and Long Maturation Periods

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