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Anterior corpus callosotomy in multistep invasive monitoring and surgery for atonic seizures

机译:前体call体切开术在无创性癫痫发作的多步侵入式监测和手术中

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Identifying the epileptogenic zone (EZ) in patients with refractory nonlesional frontal lobe epilepsy is frequently challenging. Intracranial EEG (icEEG) recordings are often required to better delineate the EZ, but the presence of an extensive network of connections allowing rapid ictal spread may result in bilateral homologous regional (or extremely diffuse) electrical ictal patterns. Here, we report a case where callosotomy performed after a first nonlateralizing icEEG study allowed for adequate identification of the EZ. The patient, an 18-year-old left-handed woman with daily atonic spells, had synchronous interictal and ictal epileptic activity from both supplementary motor areas (SMAs) during icEEG. Anterior partial callosotomy localized the EZ to the right SMA, as seizures were no longer associated with mirror-image ictal activity over the left SMA. Right SMA resection led to seizure freedom (follow-up of 23 months). This case exemplifies how a partial callosotomy followed by further icEEG recordings may adequately localize the EZ when initial icEEG recordings reveal bilateral synchronous focal or regional ictal activities.
机译:难治性非病变额叶癫痫患者的癫痫发生区(EZ)鉴定通常是具有挑战性的。通常需要颅内EEG(icEEG)记录来更好地描绘EZ,但是广泛的连接网络的存在允许快速的ictal扩散可能会导致双边同源的区域(或极度扩散的)电ictal模式。在这里,我们报告了一种情况,其中在进行首次非侧面化icEEG研究后进行了切骨术,从而可以充分识别EZ。该患者是一名18岁的左撇子妇女,每天都有无声的拼写,在icEEG期间,两个辅助运动区(SMAs)都有发作性发作间期发作和发作发作发作。由于癫痫发作不再与左侧SMA的镜象反射活动相关,因此前部部分切开术将EZ定位在右侧SMA。右SMA切除导致癫痫发作自由(随访23个月)。这种情况说明了当最初的icEEG记录显示双侧同步性局灶性或局部性发作时,在进一步的icEEG记录后进行部分call切开术可能如何充分定位EZ。

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