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首页> 外文期刊>Emerging Health Threats Journal >Effects of power frequency electromagnetic fields on melatonin and sleep in the rat
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Effects of power frequency electromagnetic fields on melatonin and sleep in the rat

机译：工频电磁场对大鼠褪黑激素和睡眠的影响

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Background: Studies investigating the effect of power frequency (50–60 Hz) electromagnetic fields (EMF) on melatonin synthesis in rats have been inconsistent with several showing suppression of melatonin synthesis, others showing no effect and a few actually demonstrating small increases. Scant research has focused on the ensuing sleep patterns of EMF exposed rats. The present study was designed to examine the effects of extremely low power frequency electromagnetic fields (EMF) on the production of melatonin and the subsequent sleep structure in rats.Methods: Eighteen male Sprague-Dawley rats were exposed to a 1000 milligauss (mG) magnetic field for 1 month. Urine was collected for the final 3 days of the exposure period for analysis of 6-sulphatoxymelatonin, the major catabolic product of melatonin found in urine. Subsequent sleep was analyzed over a 24-hour period.Results: Melatonin production was mildly increased in exposed animals. Although there were no statistically significant changes in sleep structure, exposed animals showed slight decreases in REM (rapid eye movement) sleep as compared to sham (non-exposed) animals.Conclusions: Power frequency magnetic fields induced a marginally statistically significant increase in melatonin levels in exposed rats compared to control. Subsequent sleep analysis indicated little effect on the sleep architecture of rats, at least not within the first day after 1 month's continuous exposure. Varying results in the literature are discussed and future research suggested.
机译：背景：研究电源频率（50–60 Hz）电磁场（EMF）对大鼠褪黑激素合成的影响的研究与发现褪黑激素合成受到抑制的行为不一致，其他表现出抑制褪黑激素合成作用的行为却很少表现出实际的增加。很少的研究集中在随后暴露于EMF的大鼠的睡眠模式上。本研究旨在检查极低功率电磁场（EMF）对大鼠褪黑激素产生和随后的睡眠结构的影响。方法：将18只雄性Sprague-Dawley大鼠暴露于1000毫克（mG）磁场中字段为1个月。在暴露期的最后三天收集尿液，以分析6-硫代羟黑素，这是尿液中褪黑素的主要分解代谢产物。随后24小时的睡眠进行了分析。结果：裸露的动物中褪黑激素的产量略有增加。尽管睡眠结构没有统计学上的显着变化，但与假（非暴露）动物相比，暴露的动物的REM（快速眼动）睡眠略有下降。在暴露的大鼠中与对照相比。随后的睡眠分析表明，对大鼠的睡眠结构影响很小，至少在连续暴露1个月后的第一天没有影响。讨论了文献中的各种结果，并提出了未来的研究建议。

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