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首页> 外文期刊>European Chemical Bulletin >THE EFFECT OF Hg-POLLUTED DRINKING WATER ON THE LEVEL OF HORMONES IN MALE RATS AND THE POTENTIAL THERAPEUTIC ACTION OF THE THIOSEMICARBAZONE AND ANTIPYRINE LIGANDS AND THEIR COMPLEXES
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THE EFFECT OF Hg-POLLUTED DRINKING WATER ON THE LEVEL OF HORMONES IN MALE RATS AND THE POTENTIAL THERAPEUTIC ACTION OF THE THIOSEMICARBAZONE AND ANTIPYRINE LIGANDS AND THEIR COMPLEXES

机译：汞污染的饮用水对雄性大鼠激素水平的影响以及硫咪唑烷酮和安替比林脂质及其配体的潜在治疗作用

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Novel Hg(II) complexes of d 10 configuration have been synthesized and characterized by elemental analysis, IR, UV-VIS spectra and thermal analysis. The analytical and spectral data reveal that the ligands (H 2 L 1 - HL 3 ) behave as neutral or mono basic bidentate in nature, coordinating via C=O or C-O and NH or C=N. The harmful effect of Hg-polluted drinking water on male sex hormones, kidney function as well as oxidative status biomarkers of male rats was investigated. Meanwhile, the potential protective effects of synthesized complexes and their ligands were studied. Results showed that orally administration of HgCl 2 for 30 days caused a significant disruption of male sex hormones and kidney function. Further, the level of lipid peroxidation was elevated and activities of antioxidant enzymes were markedly declined in kidney and testes homogenates. The co-administration of HgCl 2 with antipyrine and thiosemicarbazone as well as their complexes for four weeks led to amelioration in the kidney and testes functions as the levels of male sex hormones and kidney function tests were recovered. Meanwhile, these compounds showed ameliorative effects on the oxidative status of rats. It can be concluded that drinking of Hg-polluted water induces oxidative stress pathways that may lead to deterioration in kidney and testes function. The findings also suggest the curative action of antipyrine and thiosemicarbazone as well as their complexes since they exhibited the ability to resist the harmful action of mercury and to protect the organs from the action of free radicals.
机译：合成了d 10构型的新型Hg（II）配合物，并通过元素分析，IR，UV-VIS光谱和热分析进行了表征。分析和光谱数据表明，配体（H 2 L 1-HL 3）在性质上表现为中性或单碱性双齿，通过C = O或C-O和NH或C = N进行配位。研究了汞污染的饮用水对雄性大鼠雄性激素，肾脏功能以及氧化状态生物标志物的有害作用。同时，研究了合成配合物及其配体的潜在保护作用。结果表明，口服HgCl 2 30天导致男性性激素和肾功能的严重破坏。此外，肾脏和睾丸匀浆中脂质过氧化的水平升高，抗氧化酶的活性明显下降。 HgCl 2与安替比林和硫代半碳酸钠及其复合物并用四个星期导致肾脏的改善，睾丸功能随着男性性激素水平的提高而恢复。同时，这些化合物对大鼠的氧化状态显示出改善作用。可以得出结论，饮用受Hg污染的水会诱导氧化应激途径，可能导致肾脏和睾丸功能恶化。这些发现还表明安替比林和硫代半卡巴zone及其配合物的治疗作用，因为它们具有抵抗汞有害作用和保护器官免受自由基作用的能力。

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