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首页> 外文期刊>Experimental Animals >Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice
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Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice

机译：5号染色体上的数量性状基因座对DBA / 2J小鼠的听觉频率特异性影响易感性

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The DBA/2J strain is a model for early-onset, progressive hearing loss in humans, as confirmed in the present study. DBA/2J mice showed progression of hearing loss to low-frequency sounds from ultrasonic-frequency sounds and profound hearing loss at all frequencies before 7 months of age. It is known that the early-onset hearing loss of DBA/2J mice is caused by affects in the ahl ( Cdh23ahl ) and ahl8 ( Fscn2ahl8 ) alleles of the cadherin 23 and fascin 2 genes, respectively. Although the strong contributions of the Fscn2ahl8 allele were detected in hearing loss at 8- and 16-kHz stimuli with LOD scores of 5.02 at 8 kHz and 8.84 at 16 kHz, hearing loss effects were also demonstrated for three new quantitative trait loci (QTLs) for the intervals of 50.3–54.5, 64.6–119.9, and 119.9–137.0 Mb, respectively, on chromosome 5, with significant LOD scores of 2.80–3.91 for specific high-frequency hearing loss at 16 kHz by quantitative trait loci linkage mapping using a (DBA/2J × C57BL/6J) F1 × DBA/2J backcross mice. Moreover, we showed that the contribution of Fscn2ahl8 to early-onset hearing loss with 32-kHz stimuli is extremely low and raised the possibility of effects from the Cdh23ahl allele and another dominant quantitative trait locus (loci) for hearing loss at this ultrasonic frequency. Therefore, our results suggested that frequency-specific QTLs control early-onset hearing loss in DBA/2J mice.
机译：如本研究中所证实，DBA / 2J菌株是人类早期发作，进行性听力损失的模型。 DBA / 2J小鼠在7个月大之前显示出听力损失从超声声音发展为低频声音，并在所有频率上发生严重的听力损失。已知DBA / 2J小鼠的早期发作性听力损失是由钙粘蛋白的ahl（Cdh23 ahl ）和ahl8（Fscn2 ahl8 ）等位基因的影响引起的23和fascin 2基因。尽管在8和16 kHz刺激下的听力损失中检测到Fscn2 ahl8 等位基因的强大贡献，在8 kHz时LOD评分为5.02，在16 kHz时LOD评分为8.84，但对于在5号染色体上，三个新的定量性状基因座（QTL）的间隔分别为50.3–54.5、64.6–119.9和119.9–137.0 Mb，在16 kHz的特定高频听力损失中，LOD得分为2.80–3.91 （DBA / 2J×C57BL / 6J）F 1 ×DBA / 2J回交小鼠的数量性状基因座连锁图谱分析。此外，我们显示Fscn2 ahl8 对32 kHz刺激的早期发作性听力损失的贡献极低，并增加了Cdh23 ahl 等位基因和另一个主要的定量性状基因座（loci），用于该超声频率的听力损失。因此，我们的结果表明，特定频率的QTL控制DBA / 2J小鼠的早期发作性听力损失。

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