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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Quantitative trait loci analysis of tail tendon break time in mice of C57BL/6J and DBA/2J lineage.
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Quantitative trait loci analysis of tail tendon break time in mice of C57BL/6J and DBA/2J lineage.

机译：C57BL / 6J和DBA / 2J谱系小鼠尾部肌腱断裂时间的定量性状基因座分析。

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摘要

Tail tendon break time (TTBT), a measure of collagen cross-linking, shown to increase with age differs significantly among inbred strains of mice, indicating underlying genetic influences. This study was aimed to identify quantitative trait loci (QTLs) associated with tail tendon break time at three ages (200, 500, and 800 days of age) for 23 BxD recombinant inbred strains of mice and B6D2F(2) mice derived from C57BL/6J and DBA/2J strains. Heritability estimates were calculated, and QTL analyses were conducted using interval-mapping methods. Mean tail tendon break time values were higher in males and increased nonlinearly with age. Eight total QTLs were nominated in the B6D2F(2) mice at the three measured ages, with the QTL at 800 days confirmed in the recombinant inbred strains. Allelic effect modeling for the identified QTLs suggests differences in gene action between sexes. Candidate genes in the QTL regions include collagen genes and an advanced glycation end-product receptor. The QTLs identified demonstrate influence at some but not all ages.
机译：尾部肌腱断裂时间（TTBT）是一种胶原蛋白交联的量度，显示随着年龄的增长而增加，这在小鼠近交系之间存在显着差异，表明其潜在的遗传影响。这项研究旨在确定与23个BxD重组近交系小鼠和B6D2F（2）小鼠衍生自C57BL / 3的23个BxD重组近交品系在三个年龄（200、500和800天）时与尾腱断裂时间相关的定量性状位点（QTL）。 6J和DBA / 2J菌株。计算遗传力估计值，并使用区间映射方法进行QTL分析。男性的平均尾腱断裂时间值较高，并且随着年龄的增长呈非线性增加。在三个测量年龄的B6D2F（2）小鼠中提名了八个总QTL，在重组自交系中确认了800天的QTL。对鉴定出的QTL进行等位基因效应建模表明，性别之间的基因作用存在差异。 QTL区域中的候选基因包括胶原蛋白基因和高级糖基化终产物受体。所确定的QTL在某些年龄段但并非所有年龄段都显示出影响力。

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