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首页> 外文期刊>Experimental diabetes research >Exogenous Superoxide Dismutase: Action on Liver Oxidative Stress in Animals with Streptozotocin-Induced Diabetes
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Exogenous Superoxide Dismutase: Action on Liver Oxidative Stress in Animals with Streptozotocin-Induced Diabetes

机译：外源超氧化物歧化酶：对链脲佐菌素诱发的糖尿病动物肝脏氧化应激的作用。

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Aim. To investigate the effects of exogenous antioxidant copper zinc superoxide dismutase (Cu/Zn SOD) on oxidative stress in the experimental model of diabetes mellitus (DM).Methods. Twenty eight male Wistar rats divided in four groups were used: control (CO), controls treated with SOD (CO + SOD), diabetics (DM), and diabetics treated with SOD (DM + SOD). SOD (orgotein, 13 mg/Kg body weight was administered. DM was induced by a single streptozotocin injection (i.p., 70 mg/kg), and 60 days later, we evaluated liver oxidative stress.Results. Liver lipoperoxidation was increased in the DM group and significantly decreased in the DM + SOD group. Nitrite and nitrate measures were reduced in the DM and increased in the DM + SOD group, while iNOS expression in the DM group was 32% greater than in the CO and 53% greater in the DM + SOD group than in the DM group (P<.01). P65 expression was 37% higher in the DM (P<.05), and there was no significant difference between the DM and DM + SOD groups.Conclusion. SOD treatment reduced liver oxidative stress in diabetic animals, even though it did not change NFκB. SOD also increased NO, probably by the increased dismutation of the superoxide radical. The iNOS expression increase, which became even more evident after SOD administration.
机译：目标。目的探讨糖尿病模型（DM）实验模型中外源抗氧化剂铜锌超氧化物歧化酶（Cu / Zn SOD）对氧化应激的影响。使用分成四组的二十八只雄性Wistar大鼠：对照（CO），用SOD治疗的对照（CO + SOD），糖尿病（DM）和用SOD治疗的糖尿病患者（DM + SOD）。超氧化物歧化酶（草ote素，体重13μg/ Kg施用。通过单次链脲佐菌素注射（ip，70μg/ kg）诱导DM，60天后，我们评估了肝脏的氧化应激。结果，DM中的肝脂肪过氧化增加DM组中亚硝酸盐和硝酸盐含量降低，而DM + SOD组中亚硝酸盐和硝酸盐含量下降，而DM组中iNOS的表达量比CO组高32％，DM组中的iNOS表达高53％。 DM + SOD组比DM组（P <.01），DM中P65表达高37％（P <.05），DM与DM + SOD组之间无显着差异。即使不改变NFκB，治疗也能降低糖尿病小鼠的肝脏氧化应激; SOD也会增加NO的含量，这可能是由于超氧化物自由基的增加所致; iNOS的表达增加，在SOD给药后更为明显。

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