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Somatic cell nuclear transfer as a tool for investigatingageing processes in mammals

机译：体细胞核转移作为研究哺乳动物过程的工具

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The development of nuclear transfer technology has opened up a new frontier in the investigation of the processes which contribute to ageing in mammals. This review seeks to assess the individual hypotheses that have been proposed to account for the development of the ageing phenotype and to ask how they correlate with observations made on cloned mammals. In sheep derived by nuclear transfer there appears to be prematurely shortened telomeres, indicative of increased age. The animals, however, are physiologically normal, consistent with a redox model of ageing where mitochondrial damage is the key contributory factor. The application of nuclear transfer technology to the study of ageing phenomena and its use in experimentally redressing aspects of the ageing phenotype is discussed.
机译：核移植技术的发展为研究导致哺乳动物衰老的过程开辟了一个新领域。这篇综述旨在评估提出的假说以解释衰老表型的发展，并询问它们与克隆哺乳动物的观察结果如何相关。在通过核转移获得的绵羊中，端粒过早缩短，表明年龄增加。然而，这些动物在生理上是正常的，与衰老的氧化还原模型一致，其中线粒体的损​​伤是关键的因素。讨论了核转移技术在衰老现象研究中的应用及其在衰老表型的实验矫正方面的应用。

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