Nuclear prostaglandin receptors

Dr. Sylvain Chemtob

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Nuclear prostaglandin receptors

机译：核前列腺素受体

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Prostaglandins and thromboxane are ubiquitous compounds and play important roles in cardiovascular homeostasis, inflammation, reproduction, respiration, mitogenesis and gene transcription and so on. These actions of prostanoids are presumed to be mediated by plasma membrane receptors belonging to the superfamily of G protein-coupled receptors. However, several lines of evidence suggest prostanoids may also act at the nuclear level. Nuclei contain cyclooxygenases and other intermediates required for prostanoid synthesis and receptor-mediated responses. This review focuses closely on various signal transduction cascades that exist in the nuclear membranes, including the presence of other nuclear G protein-coupled receptor, and discusses the discovery of functional nuclear prostaglandin E2 receptor. These data add new dimensions to the functions and signaling mediated by prostaglandin receptors.

机译：前列腺素和血栓烷是普遍存在的化合物，在心血管稳态，炎症，繁殖，呼吸，有丝分裂和基因转录等方面起着重要作用。推测类前列腺素的这些作用是由属于G蛋白偶联受体超家族的质膜受体介导的。但是，有几条证据表明类前列腺素也可能在核水平上起作用。核含有环加氧酶和前列腺素合成和受体介导的反应所需的其他中间体。这篇综述密切关注存在于核膜上的各种信号转导级联反应，包括其他核G蛋白偶联受体的存在，并讨论了功能性核前列腺素E2受体的发现。这些数据为前列腺素受体介导的功能和信号传导增加了新的维度。

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《Gene Therapy and Molecular Biology》 |1999年第3期|共16页
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Dr. Sylvain Chemtob;
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1. Prostaglandins and fatty acids regulate transcriptional signaling via the peroxisome proliferator activated receptor nuclear receptors. [J] . Dussault I, Forman BM Prostaglandins . 2000,第1期

机译：前列腺素和脂肪酸通过过氧化物酶体增殖物激活的受体核受体调节转录信号。
2. Luteinizing hormone-induced expression of Ptger4b, a prostaglandin E2 receptor indispensable for ovulation of the medaka Oryzias latipes, is regulated by a genomic mechanism involving nuclear progestin receptor [J] . HagiwaraA., OgiwaraK., KatsuY., Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction . 2014,第6期

机译：黄体激素诱导的Ptger4b的表达是由涉及核孕激素受体的基因组机制调节的，Ptger4b是必不可少的Medaka Oryzias latipes排卵的前列腺素E2受体。
3. Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B. [J] . Berry EB, Keelan JA, Helliwell RJ, Molecular pharmacology. . 2005,第1期

机译：15-脱氧-δ12,14-前列腺素J2对羊膜来源的WISH上皮细胞的纳摩尔和微摩尔作用：过氧化物酶体增殖物激活受体γ和δ与核因子κB的不同作用。
4. Nuclear progesterone receptor is involved in the LH-induced expression of Ptger4b, a prostaglandin E_2 receptor indispensable for ovulation of the medaka [C] . Hagiwara A., Ogiwar K., Katsu Y., International Congress of Comparative Endocrinology . 2014

机译：核孕酮受体参与LH诱导的PTING4B表达，前列腺素E_2受体对于麦卡卡的排卵是必不可少的
5. Activation of novel signal transduction pathways by human EP1 prostanoid receptors: The G-protein coupled receptors for prostaglandin E2. [D] . Ji, Ruyue. 2010

机译：人类EP1前列腺素受体激活新的信号转导途径：前列腺素E2的G蛋白偶联受体。
6. Nuclear localization of prostaglandin E2 receptors [O] . Mousumi Bhattacharya, Krishna G. Peri, Guillermina Almazan, 1998

机译：前列腺素E2受体的核定位
7. Nuclear localization of prostaglandin E2 receptors [O] . Bhattacharya, Mousumi, Peri, Krishna G., Almazan, Guillermina, 1998

机译：前列腺素E2受体的核定位
8. Prostaglandin E2 Receptor Expression by Osteoblasts is Modulated by Implant Surface Roughness and Prostaglandin E2 [R] . Campbell, M. M. 2006

机译：成骨细胞的前列腺素E2受体表达受植入物表面粗糙度和前列腺素E2的调节。

Nuclear prostaglandin receptors

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