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首页> 外文期刊>Gene Therapy and Molecular Biology >GADD45? Methylation Is More Common InBenign Prostatic Hyperplasia Than In ProstateCancer
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GADD45? Methylation Is More Common InBenign Prostatic Hyperplasia Than In ProstateCancer

机译：GADD45？甲基化在良性前列腺增生中比在前列腺癌中更常见

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Prostate cancer (PCa) is one of the most common cancer types worldwide in men. AlthoughGrowth Arrest DNA Damage-Inducible 45 (GADD45) family members, GADD45?, GADD45? and GADD45?, are responsible for the activation of several molecules in certain cellular pathwaysaffecting cell fate, including tumorigenesis, as stress sensors, the role of GADD45? in PCa is still not clear. In this study, our aim was to detect the methylation and protein expression profiles of GADD45? in benign prostate hyperplasia (BPH) (60 patients) and PCa (56 patients). The methylation of GADD45? was determined by methylation-sensitive high resolution melting analysis. Immunohistochemistry was used for evaluating GADD45? protein expression. The methylation frequency for GADD45? was as low as 1.8% in PCa compared with BPH (P=0.000). GADD45? protein was overexpressed in PCa cases (53.6%) compared with the BPH cases (33.3%), and the difference was statistically different (P=0.028). There was no correlation between GADD45? methylation and protein expression in both groups. This study shows that in contrast to hematological malignencies, GADD45? methylation is not one of the common epigenetic changes in PCa. In addition, we suggest that the loss of important regulatory mechanisms involved in GADD45? might play a role in the pathogenesis of BPH.
机译：前列腺癌（PCa）是全球男性中最常见的癌症类型之一。尽管生长抑制DNA诱导诱导45（GADD45）家族成员是GADD45？，GADD45？ GADD45？和GADD45？负责激活某些影响细胞命运的细胞途径（包括肿瘤发生）中的几种分子，作为应激传感器，GADD45？的作用。在PCa中仍不清楚。在这项研究中，我们的目的是检测GADD45？的甲基化和蛋白质表达谱。前列腺增生（BPH）（60例）和PCa（56例）。 GADD45的甲基化？通过甲基化敏感的高分辨率熔解分析确定。免疫组织化学用于评估GADD45？蛋白表达。 GADD45的甲基化频率？与BPH相比，PCa中的低至1.8％（P = 0.000）。 GADD45？与BPH病例（33.3％）相比，PCa病例（53.6％）的蛋白过表达，差异有统计学意义（P = 0.028）。 GADD45之间没有相关性？两组中的甲基化和蛋白质表达。这项研究表明，与血液系统恶性肿瘤相比，GADD45？甲基化不是PCa常见的表观遗传变化之一。此外，我们建议GADD45参与重要调控机制的丧失？可能在BPH的发病机理中起作用。

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