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The HSV-TK/GCV gene therapy for brain tumors

机译:HSV-TK / GCV基因治疗脑肿瘤

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Herpes simplex virus-thymidine kinase (HSV-TK) gene transduction followed by ganciclovir (GCV) administration is widely used for cancer treatment as a "suicide gene" therapy. The present review describes the HSV-TK/GCV gene therapy for brain tumors (gliomas) through the eyes of a clinician, including a review of preclinical and clinical studies. In particular, the latest data on the first clinical trial are discussed and, moreover, the surgical procedures are depicted. The surgical technique is the most important for neurosurgeons; therefore, its improvement would be beneficial for further clinical developments as well as biological innovation of retroviral vectors or vector producer cells.
机译:单纯疱疹病毒-胸苷激酶(HSV-TK)基因转导,然后更昔洛韦(GCV)给药被广泛用作“自杀基因”疗法用于癌症治疗。本综述通过临床医生的眼球描述了针对脑肿瘤(神经胶质瘤)的HSV-TK / GCV基因疗法,包括对临床前和临床研究的综述。特别是,讨论了有关首次临床试验的最新数据,此外,还描述了手术程序。对于神经外科医生来说,手术技术是最重要的。因此,其改进将对进一步的临床发展以及逆转录病毒载体或载体生产细胞的生物学创新都是有益的。

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