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首页> 外文期刊>Genes and Nutrition >Gender differences in Nociceptin/Orphanin FQ-induced food intake in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome: a possible involvement of the cocaine- and amphetamine-regulated transcript system
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Gender differences in Nociceptin/Orphanin FQ-induced food intake in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome: a possible involvement of the cocaine- and amphetamine-regulated transcript system

机译：易感（WOKW）和抗药性（Dark Agouti）大鼠新陈代谢综合症中的品系中，伤害感受肽/孤啡肽FQ诱导的食物摄入的性别差异：可卡因和苯丙胺调节的转录系统可能参与

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Our previous study found that when injected with Nociceptin/Orphanin FQ (N/OFQ) into the brain, male Dark Agouti (DA) rats, which are resistant to metabolic syndrome, have greater hyperphagia than male Wistar Ottawa Karlsburg W (WOKW) animals, which are prone to this disease. We attributed this difference to the fact that these two strains have different cocaine-amphetamine regulated transcript peptide (Cart) gene sequences and expression. In order to address this hypothesis, the present work focused on sex differences and analyzed not only male but also female N/OFQ-induced (0.25 and 0.5?nmol/rat) food intake in terms of their Cart and N/OFQ receptor gene expression in the hypothalamic area. In N/OFQ-naive WOKW females, cart gene expression is extremely elevated compared to N/OFQ-naive WOKW males. When male and female WOKW littermates are stimulated with N/OFQ, the food intake of females is significantly lower than that of the males. Granted, the N/OFQ feeding behavior experiments were not performed on the animals measured for Cart gene expression, but nonetheless, the responses observed in littermates point to an interesting avenue for further inquiry.
机译：我们之前的研究发现，当向大脑中注射Nociceptin / Orphanin FQ（N / OFQ）时，对代谢综合征具有抵抗力的雄性Dark Agouti（DA）大鼠比雄性Wistar Ottawa Karlsburg W（WOKW）动物具有更大的食欲，容易发生这种疾病。我们将此差异归因于以下事实：这两个菌株具有不同的可卡因-苯丙胺调节的转录肽（Cart）基因序列和表达。为了解决这个假设，本研究着重于性别差异，不仅分析了男性，还分析了N / OFQ诱导的（0.25和0.5？nmol /大鼠）Cart和N / OFQ受体基因表达的女性摄食量。在下丘脑区域。在N / OFQ天真WOKW雌性中，与N / OFQ天真WOKW雄性相比，cart基因表达极高。当用N / OFQ刺激雄性和雌性WOKW同窝仔时，雌性的食物摄入量显着低于雄性。当然，未对测量Cart基因表达的动物进行N / OFQ喂养行为实验，但尽管如此，在同窝幼仔中观察到的反应为进一步研究提供了一条有趣的途径。

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