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首页> 外文期刊>Genome Biology and Evolution >First Complete Mitochondrial Genome Sequence from a Box Jellyfish Reveals a Highly Fragmented Linear Architecture and Insights into Telomere Evolution
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First Complete Mitochondrial Genome Sequence from a Box Jellyfish Reveals a Highly Fragmented Linear Architecture and Insights into Telomere Evolution

机译：盒状水母中第一个完整的线粒体基因组序列揭示了高度碎片化的线性结构，并揭示了端粒的进化

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Animal mitochondrial DNAs (mtDNAs) are typically single circular chromosomes, with the exception of those from medusozoan cnidarians (jellyfish and hydroids), which are linear and sometimes fragmented. Most medusozoans have linear monomeric or linear bipartite mitochondrial genomes, but preliminary data have suggested that box jellyfish (cubozoans) have mtDNAs that consist of many linear chromosomes. Here, we present the complete mtDNA sequence from the winged box jellyfish Alatina moseri (the first from a cubozoan). This genome contains unprecedented levels of fragmentation: 18 unique genes distributed over eight 2.9- to 4.6-kb linear chromosomes. The telomeres are identical within and between chromosomes, and recombination between subtelomeric sequences has led to many genes initiating or terminating with sequences from other genes (the most extreme case being 150 nt of a ribosomal RNA containing the 5′ end of nad2), providing evidence for a gene conversion–based model of telomere evolution. The silent-site nucleotide variation within the A. moseri mtDNA is among the highest observed from a eukaryotic genome and may be associated with elevated rates of recombination.
机译：动物线粒体DNA（mtDNA）通常是单个圆形染色体，但来自线虫有时甚至是片段化的中生动物id虫（水母和水体）的染色体除外。大多数中生动物具有线性单体或线性二分体线粒体基因组，但初步数据表明，箱形水母（cubozoans）的mtDNA由许多线性染色体组成。在这里，我们介绍了来自有翅盒水母Alatina moseri（第一个来自立方动物）的完整mtDNA序列。该基因组包含前所未有的片段化水平：18个独特的基因分布在八个2.9-4.6kb线性染色体上。染色体内和染色体之间的端粒是相同的，亚端粒序列之间的重组导致许多基因起始或终止于其他基因的序列（最极端的情况是含有nad2的5'端的核糖体RNA的150 nt）。基于基因转换的端粒进化模型。从真核生物基因组中观察到的A. moseri mtDNA内沉默位点核苷酸变异最高，并且可能与重组率升高有关。

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