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Relationship of common expression quantitative trait loci genes to the immune system

机译：共同表达数量性状基因座基因与免疫系统的关系

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Tissue-specific expression quantitative trait loci (eQTLs) are always linked to specific diseases. In this study, we focused on eQTLs common to multiple tissues and explored their functional mechanisms in disease for the first time. We found 11 common eQTL genes among multiple tissues. Five genes were validated through a genome-wide association study, 3 genes were validated using the Online Mendelian Inheritance in Man database, and the others were validated through text mining. Most of these disorders were related to the systemic immune system. In functional analyses using Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes, these common eQTL genes were enriched in biological processes and pathways mostly related to the immunity. Therefore, we believe that these common eQTL genes are related to immune system.
机译：组织特异性表达定量性状基因座（eQTL）始终与特定疾病相关。在这项研究中，我们专注于多种组织共有的eQTL，并首次探讨了它们在疾病中的功能机制。我们在多个组织中发现了11个常见的eQTL基因。通过全基因组关联研究验证了5个基因，使用在线孟德尔遗传在线数据库验证了3个基因，其余的通过文本挖掘验证了。这些疾病大多数与全身免疫系统有关。在使用基因本体论和《京都议定书》的基因和基因组百科全书进行功能分析时，这些常见的eQTL基因丰富了与免疫力有关的生物学过程和途径。因此，我们认为这些常见的eQTL基因与免疫系统有关。

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