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首页> 外文期刊>Genomics >Comparative gene expression analysis in mouse models for multiple sclerosis, Alzheimer's disease and stroke for identifying commonly regulated and disease-specific gene changes
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Comparative gene expression analysis in mouse models for multiple sclerosis, Alzheimer's disease and stroke for identifying commonly regulated and disease-specific gene changes

机译：在多发性硬化症，阿尔茨海默氏病和中风的小鼠模型中进行比较性基因表达分析，以鉴定通常调控的和疾病特异性的基因变化

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The brain responds to injury and infection by activating innate defense and tissue repair mechanisms. Working upon the hypothesis that the brain defense response involves common genes and pathways across diverse pathologies, we analysed global gene expression in brain from mouse models representing three major central nervous system disorders, cerebral stroke, multiple sclerosis and Alzheimer's disease compared to normal brain using DNA microarray expression profiling. A comparison of dysregulated genes across disease models revealed common genes and pathways including key components of estrogen and TGF-β signaling pathways that have been associated with neuroprotection as well as a neurodegeneration mediator, TRPM7. Further, for each disease model, we discovered collections of differentially expressed genes that provide novel insight into the individual pathology and its associated mechanisms. Our data provide a resource for exploring the complex molecular mechanisms that underlie brain neurodegeneration and a new approach for identifying generic and disease-specific targets for therapy.
机译：大脑通过激活先天防御和组织修复机制来响应伤害和感染。基于大脑防御反应涉及不同病理的共同基因和途径的假设，我们使用DNA来分析代表三种主要中枢神经系统疾病，脑中风，多发性硬化症和阿尔茨海默氏病的小鼠模型在大脑中的整体基因表达，微阵列表达谱。跨疾病模型的失调基因的比较揭示了常见的基因和途径，包括与神经保护相关的雌激素和TGF-β信号传导途径的关键成分以及神经退变介质TRPM7。此外，对于每种疾病模型，我们发现了差异表达基因的集合，这些基因为个体病理及其相关机制提供了新颖的见解。我们的数据为探索脑神经变性基础的复杂分子机制提供了资源，并为确定通用和针对疾病的治疗靶标提供了新方法。

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