Clinical genomics information management software linking cancer genome sequence and clinical decisions

Stuart Watt; Wei Jiao; Andrew M.K. Brown; Teresa Petrocelli; Ben Tran; Tong Zhang; John D. McPherson; Suzanne Kamel-Reid; Philippe L. Bedard; Nicole Onetto; Thomas J. Hudson; Janet Dancey; Lillian L. Siu; Lincoln Stein; Vincent Ferretti

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Clinical genomics information management software linking cancer genome sequence and clinical decisions

机译：临床基因组信息管理软件将癌症基因组序列与临床决策联系起来

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Usingsequencinginformationtoguideclinicaldecision-makingrequirescoordinationofadiversesetofpeopleandactivities.Inclinicalgenomics,theprocesstypicallyincludessampleacquisition,templatepreparation,genomedatageneration,analysistoidentifyandconfirmvariantalleles,interpretationofclinicalsignificance,andreportingtoclinicians.Wedescribeasoftwareapplicationdevelopedwithinaclinicalgenomicsstudy,tosupportthisentireprocess.Thesoftwareapplicationtrackspatients,samples,genomicresults,decisionsandreportsacrossthecohort,monitorsprogressandsendsreminders,andworksalongsideanelectronicdatacapturesystemforthetrial'sclinicalandgenomicdata.Itincorporatessystemstoread,store,analyzeandconsolidatesequencingresultsfrommultipletechnologies,andprovidesacuratedknowledgebaseoftumormutationfrequency(fromtheCOSMICdatabase)annotatedwithclinicalsignificanceanddrugsensitivitytogeneratereportsforclinicians.Bysupportingtheentireprocess,theapplicationprovidesdeepsupportforclinicaldecisionmaking,enablingthegenerationofrelevantguidanceinreportsforverificationbyanexpertpanelpriortoforwardingtothetreatingphysician./p/div

机译：Usingsequencinginformationtoguideclinicaldecision-makingrequirescoordinationofadiversesetofpeopleandactivities.Inclinicalgenomics，theprocesstypicallyincludessampleacquisition，templatepreparation，genomedatageneration，analysistoidentifyandconfirmvariantalleles，interpretationofclinicalsignificance，andreportingtoclinicians.Wedescribeasoftwareapplicationdevelopedwithinaclinicalgenomicsstudy，tosupportthisentireprocess.Thesoftwareapplicationtrackspatients，样品，genomicresults，decisionsandreportsacrossthecohort，monitorsprogressandsendsreminders，andworksalongsideanelectronicdatacapturesystemforthetrial'sclinicalandgenomicdata.Itincorporatessystemstoread，存储，analyzeandconsolidatesequencingresultsfrommultipletechnologies，andprovidesacuratedknowledgebaseoftumormutationfrequency（fromtheCOSMICdatabase）annotatedwithclinicalsignificanceanddrugsensitivitytogeneratereportsforclinicians.Bysupportingtheentireprocess，该应用程序为临床决策制定提供了深层支持，从而实现了相关信息的生成在由专家小组进行审核之前，必须先提出指导意见，然后再转给治疗医师。

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《Genomics》 |2013年第3期|共页
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Stuart Watt; Wei Jiao; Andrew M.K. Brown; Teresa Petrocelli; Ben Tran; Tong Zhang; John D. McPherson; Suzanne Kamel-Reid; Philippe L. Bedard; Nicole Onetto; Thomas J. Hudson; Janet Dancey; Lillian L. Siu; Lincoln Stein; Vincent Ferretti;
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中图分类医学遗传学;
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1. Clinical genomics information management software linking cancer genome sequence and clinical decisions [J] . WattS., JiaoW., BrownA.M.K., Genomics . 2013,第3期

机译：临床基因组信息管理软件将癌症基因组序列与临床决策联系起来
2. Impact of tissue-based genomic profiling on clinical decision making in the management of patients with metastatic breast cancer at academic centers [J] . Santa-Maria Cesar A., Kruse Megan, Raska Paola, Breast cancer research and treatment. . 2017,第1期

机译：基于组织基因组分析对学术中心转移乳腺癌患者临床决策的影响
3. "Stemness" genomics law governs clinical behavior of human cancer: implications for decision making in disease management. [J] . Glinsky GV Journal of Clinical Oncology . 2008,第17期

机译：“ Stemness”基因组学法则支配着人类癌症的临床行为：对疾病管理决策的影响。
4. A FRAMEWORK FOR CANCER DECISION SUPPORT BASED ON PROFILING BY INTEGRATING CLINICAL AND GENOMIC DATA: APPLICATION TO COLON CANCER [C] . T.P. EXARCHOSN. GIANNAKEASY. GOLETSISC. PAPALOUKASD.I. FOTIADIS International Workshop on Mathematical Methods in Scattering Theory and Biomedical Engineering . 2008

机译：通过整合临床和基因组数据的分析：对结肠癌的癌症癌症决策支持的框架
5. Clinical decision support for the whole genome sequence. [D] . Welch, Brandon Marshall. 2014

机译：全基因组序列的临床决策支持。
6. Polypharmacy in an Elderly Population: Enhancing Medication Management Through the Use of Clinical Decision Support Software Platforms [O] . Dorothy Keine, Mark Zelek, John Q. Walker, 2019

机译：老年人口的多药店：通过使用临床决策支持软件平台来加强药物管理
7. Clinical genomics information management software linking cancer genome sequence and clinical decisions [O] . Watt Stuart, Jiao Wei, Brown Andrew M.K., 2013

机译：临床基因组信息管理软件将癌症基因组序列与临床决策联系起来
8. Evaluation of a Computerized Clinical Decision Support System and EHR-Linked Registry to Improve the Management of Hypertension in a Community Health Center. Inclusive Project Dates: 09/29/07 - 06/30/11. [R] . Kopal, H. 2016

机译：评估计算机化临床决策支持系统和EHR链接注册表，以改善社区卫生服务中心的高血压管理。包容性项目日期：09/29/07 - 06/30/11。

Clinical genomics information management software linking cancer genome sequence and clinical decisions

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