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Quaternary cocrystals: combinatorial synthetic strategies based on long-range synthon Aufbau modules (LSAM)

机译:第四元共晶体:基于远程合成子Aufbau模块(LSAM)的组合合成策略

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A synthetic strategy is outlined whereby a binary cocrystal may be developed in turn into a ternary and finally into a quaternary cocrystal. The strategy hinges on the concept of the long-range synthon Aufbau module (LSAM) which is a large supramolecular synthon containing more than one type of intermolecular interaction. Modulation of these interactions may be possible with the use of additional molecular components so that higher level cocrystals are produced. We report six quaternary cocrystals here. All are obtained as nearly exclusive crystallization products when four appropriate solid compounds are taken together in solution for crystallization.
机译:概述了合成策略,由此可以将二元共晶体依次发展为三元,最后发展为四元共晶体。该策略取决于远程合成子Aufbau模块(LSAM)的概念,该模块是一个大型超分子合成子,包含多种类型的分子间相互作用。这些相互作用的调节可以通过使用额外的分子组分来实现,从而产生更高水平的共晶体。我们在这里报告了六个四元共晶体。当将四种合适的固体化合物一起溶解在结晶溶液中时,所有化合物几乎都是专有的结晶产物。

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