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首页> 外文期刊>Genetics, selection, evolution >Fatness QTL on chicken chromosome 5 and interaction with sex
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Fatness QTL on chicken chromosome 5 and interaction with sex

机译：鸡5号染色体上的脂肪QTL及其与性的相互作用

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摘要

Quantitative trait loci (QTL) affecting fatness in male chickens were previously identified on chromosome 5 (GGA5) in a three-generation design derived from two experimental chicken lines divergently selected for abdominal fat weight. A new design, established from the same pure lines, produced 407 F2 progenies (males and females) from 4 F1-sire families. Body weight and abdominal fat were measured on the F2 at 9 wk of age. In each sire family, selective genotyping was carried out for 48 extreme individuals for abdominal fat using seven microsatellite markers from GGA5. QTL analyses confirmed the presence of QTL for fatness on GGA5 and identified a QTL by sex interaction. By crossing one F1 sire heterozygous at the QTL with lean line dams, three recombinant backcross 1 (BC1) males were produced and their QTL genotypes were assessed in backcross 2 (BC2) progenies. These results confirmed the QTL by sex interaction identified in the F2 generation and they allow mapping of the female QTL to less than 8 Mb at the distal part of the GGA5. They also indicate that fat QTL alleles were segregating in both fat and lean lines.
机译：先前在三代设计中从影响腹部脂肪重量的两条实验鸡品系衍生出的三代设计中，在5号染色体（GGA5）上鉴定了影响雄性鸡脂肪的数量性状基因位点（QTL）。采用相同的纯系建立的新设计从4个F1父亲家庭中产生了407个F2后代（雄性和雌性）。在9周龄时在F 2 上测量体重和腹部脂肪。在每个父亲家庭中，使用七个来自GGA5的微卫星标记对48个极端的腹部脂肪个体进行了基因分型。 QTL分析证实了GGA5上存在QTL脂肪，并通过性别相互作用鉴定了QTL。通过在QTL上将一个F1父系杂合子与瘦线水坝杂交，产生了3个重组回交1（BC1）雄性，并在回交2（BC2）后代中评估了它们的QTL基因型。这些结果通过在F2代中鉴定出的性别相互作用证实了QTL，并且它们允许女性QTL在GGA5的远端映射到小于8 Mb。他们还表明，脂肪QTL等位基因在脂肪和瘦肉系中均处于隔离状态。

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