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Biomaterials in cochlear implants

机译:人工耳蜗中的生物材料

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The cochlear implant (CI) represents, for almost 25 years now, the gold standard in the treatment of children born deaf and for postlingually deafened adults. These devices thus constitute the greatest success story in the field of ‘neurobionic’ prostheses. Their (now routine) fitting in adults, and especially in young children and even babies, places exacting demands on these implants, particularly with regard to the biocompatibility of a CI’s surface components. Furthermore, certain parts of the implant face considerable mechanical challenges, such as the need for the electrode array to be flexible and resistant to breakage, and for the implant casing to be able to withstand external forces. As these implants are in the immediate vicinity of the middle-ear mucosa and of the junction to the perilymph of the cochlea, the risk exists – at least in principle – that bacteria may spread along the electrode array into the cochlea. The wide-ranging requirements made of the CI in terms of biocompatibility and the electrode mechanism mean that there is still further scope – despite the fact that CIs are already technically highly sophisticated – for ongoing improvements to the properties of these implants and their constituent materials, thus enhancing the effectiveness of these devices. This paper will therefore discuss fundamental material aspects of CIs as well as the potential for their future development.
机译:耳蜗植入物(CI)代表了将近25年的治疗聋儿和聋哑成年人的金标准。因此,这些装置构成了“神经胶质”假体领域最大的成功案例。它们(现在是常规的)适合成人,尤其是年幼的孩子甚至是婴儿,对这些植入物提出了严格的要求,特别是在CI表面成分的生物相容性方面。此外,植入物的某些部分面临相当大的机械挑战,例如需要电极阵列具有挠性和耐破损性,并且植入物外壳必须能够承受外力。由于这些植入物紧邻中耳黏膜以及与耳蜗周围淋巴的交界处,因此存在细菌的风险(至少在原则上),可能会沿电极阵列扩散到耳蜗中。 CI在生物相容性和电极机理方面的广泛要求意味着,尽管CI在技术上已经非常复杂,但仍存在进一步的范围,以不断改善这些植入物及其组成材料的性能,从而提高了这些设备的效率。因此,本文将讨论CI的基本实质内容以及它们未来的发展潜力。

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