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首页> 外文期刊>Gynecologic Oncology Reports >Prolonged response to exemestane following multiple surgical resections and hormonal therapies in a patient with recurrent endometrial stromal sarcoma
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Prolonged response to exemestane following multiple surgical resections and hormonal therapies in a patient with recurrent endometrial stromal sarcoma

机译：复发性子宫内膜间质肉瘤患者多次手术切除和激素治疗后对依西美坦的反应延长

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Background Endometrial stromal sarcomas (ESSs) are rare, indolent tumors with high recurrence rates. Management includes surgery and hormonal therapy given high estrogen and progesterone receptor (ER/PR) expression. Case A pre-menopausal patient with stage II ESSs (ER +/PR +) underwent primary surgery followed by adjuvant megestrol. Recurrence in the bladder/upper vagina (ER +/PR ?) was diagnosed one year later and treated with anterior pelvic exenteration and adjuvant letrozole. Two years later she recurred and was treated with radical surgery and adjuvant exemestane therapy (tumor ER strongly +/PR +). The patient then had a five-year disease free interval before being diagnosed with her third recurrence (ER +). Conclusion Exemestane treatment for ESSs can lead to a prolonged response, even in the setting of progression after prior aromatase inhibitor treatment. Highlights ? Aromatase inhibitors (AIs) are used in the treatment of endometrial stromal sarcoma. ? Letrozole and anastrozole are type 2 reversible nonsteroidal AIs. ? Exemestane is a type 1 irreversible steroidal AI. ? Exemestane demonstrated a prolonged clinical response and is well-tolerated.
机译：背景子宫内膜间质肉瘤（ESS）是罕见的惰性肿瘤，复发率高。管理包括给予高雌激素和孕激素受体（ER / PR）表达的手术和激素疗法。案例绝经前患有II期ESS（ER + / PR +）的患者接受了一次基础手术，然后接受了辅助孕酮。一年后被诊断出膀胱/上阴道复发（ER + / PR？），并用盆腔前部引出术和来曲唑辅助治疗。两年后，她复发了，并接受了根治性手术和辅助的依西美坦治疗（强烈的ER ER + / PR +肿瘤）。然后，该患者在被诊断为第三次复发（ER +）之前有五年无病间隔。结论依西美坦治疗ESS可以延长反应时间，即使在先前进行芳香酶抑制剂治疗后仍可进展。强调 ？芳香酶抑制剂（AIs）用于治疗子宫内膜间质肉瘤。 ？来曲唑和阿那曲唑是2型可逆非甾体类AI。 ？依西美坦是一种1型不可逆类固醇AI。 ？依西美坦显示出延长的临床反应，并且耐受性良好。

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