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首页> 外文期刊>Gynecologic Oncology Reports >Everolimus and papillomavirus lesions in female renal transplant recipient: A case report
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Everolimus and papillomavirus lesions in female renal transplant recipient: A case report

机译：女性肾移植受者的依维莫司和乳头瘤病毒病灶：1例报告

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摘要

We describe the case of a transplanted patient with high-risk HPV infection that manifested as multiple genital condylomas and abnormal Papanicolaou (Pap) smear. Her immunosuppressants were corticosteroids, cyclosporine, and azathioprine. Since gynecologic treatments to eradicate condylomas were completely unsuccessful, cyclosporine was replaced by everolimus. Soon after, condylomas disappeared, HPV status became negative, and Pap smear returned to normal and has remained normal since. Highlights ? Kidney transplant recipients with hrHPV infection require close monitoring. ? Close monitoring also includes changes in IS therapy with emphasis on mTORi. ? mTOR signaling pathway is activated in HPV-positive and negative cervical carcinoma. ? Switching to mTORi has helped our patient to fully normalize gynecological findings.
机译：我们描述了高危型HPV感染的移植患者的情况，该患者表现为多个生殖器con突和异常的Papanicolaou（Pap）涂片。她的免疫抑制剂是皮质类固醇，环孢素和硫唑嘌呤。由于根除dy突的妇科治疗是完全不成功的，因此环孢霉素被依维莫司替代。此后不久，con突消失，HPV状态变为阴性，子宫颈抹片检查恢复正常，此后一直保持正常。强调 ？ hrHPV感染的肾移植受者需要密切监测。 ？密切监测还包括以mTORi为重点的IS治疗的变化。 ？在HPV阳性和阴性宫颈癌中，mTOR信号通路被激活。 ？改用mTORi已帮助我们的患者使妇科检查结果完全正常化。

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