OP?IUNI TERAPEUTICE ?N DIABET: INSULINA CLIVABIL?DE FURINA ?I EXPRIMAT? ?N CELULE STEM MEZENCHIMALE

OANA I GAVRILIUC; FLORINA M BOJIN; VIRGIL PAUNESCU

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OP?IUNI TERAPEUTICE ?N DIABET: INSULINA CLIVABIL?DE FURINA ?I EXPRIMAT? ?N CELULE STEM MEZENCHIMALE

机译：糖尿病的治疗选择：面粉和表达的临床胰岛素？在间充质干细胞中

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?n pofida unor progrese recente ?n domeniul transdiferen?ierii chimice a celulelor mezenchimale umane sau de?obolan ?n celule secretoare de insulin?, eficein?a ?i aplicabilitatea clinic? a acestor metode este chestionabil?. ?ncontrast, celule mezenchimale umane modificate genetic, capabile de secre?ie pe termen lung, controlabil?, ainsulinei mature, activ? biologic, ar putea reprezenta o solu?ie terapeutic? promi??toare pentru tratarea diabetului.?n acest studiu, am explorat posibilitatea de a ob?ine vectori genetici de tip plasmid pe care s? con?in? unconstruct de proinsulin? uman?, ?n care situsurile de clivare ale enzimelor PC1/3 ?i PC2 au fost modificategenetic prin mutagenez? ?n situsuri de clivare penmtru furin?. Am urmarit ca aceast? transgen? pentru insulin?sa poat? fi transcrisa corect ?i la un nivel ?nalt de expresie prin transferul non-viral ?n celule stem mezenchimaleumane.

机译：尽管在人或大鼠间充质细胞化学转分化为分泌胰岛素的细胞方面取得了新进展，但疗效和临床适用性如何？这些方法中有问题吗？相反，转基因的人间充质细胞能够长期，可控地分泌成熟的活性胰岛素。从生物学上讲，可以代表一种治疗方案吗？有望用于治疗糖尿病在这项研究中，我们探索了获得可用于治疗糖尿病的质粒型遗传载体的可能性。骗？前胰岛素构建体？其中的PC1 / 3和PC2酶的切割位点已通过诱变进行了遗传修饰？在弗林蛋白酶的裂解位点。我有看过吗变性人？胰岛素？通过非病毒转移到间充质干细胞中被正确转录并以高水平表达。

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《Fiziologia: official journal of the Romanian Society of Physiological Sciences》 |2015年第4期|共1页
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OANA I GAVRILIUC; FLORINA M BOJIN; VIRGIL PAUNESCU;
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OP?IUNI TERAPEUTICE ?N DIABET: INSULINA CLIVABIL?DE FURINA ?I EXPRIMAT? ?N CELULE STEM MEZENCHIMALE

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