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Association of whole grain, refined grain, and cereal consumption with gastric cancer risk: A meta‐analysis of observational studies

机译：全谷物，精制谷物和谷物摄入量与胃癌风险的关联：观察性研究的荟萃分析

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Many studies have analyzed the relationship between cereal, whole, or refined grain and the risk of gastric cancer (GC) and have yielded mixed results. Therefore, we performed a meta‐analysis of observational studies to summarize the available evidence on this topic. Databases such as PubMed, EMBASE, Web of Science, MEDLINE, and the Cochrane Library were searched for studies focusing on these associations from inception to October 2017. Summary odd ratios (OR) and 95% confidence intervals (CI) were calculated by using either a random‐ or fixed‐effect model according to the between‐studies heterogeneity. Subgroup analysis was also performed. In total, eleven studies that included 530,176 participants were identified. In a pooled analysis of all studies, cereal exposure was not associated with GC risk (OR, 1.11, 95%CI, 0.85–1.36). Specific analyses indicated that whole grain consumption was associated with decreased GC risk (OR, 0.61, 95%CI, 0.40–0.83) and that refined grain consumption was associated with increased GC risk (OR, 1.65, 95%CI, 1.36–1.94). Higher whole grain and lower refined grain intake but not cereal consumption reduces GC risk. This study has been registered at ClinicalTrials.gov (ID: NCT03419663).
机译：许多研究分析了谷物，粗粮或精炼谷物与胃癌（GC）风险之间的关系，并得出了不同的结果。因此，我们对观察性研究进行了荟萃分析，以总结有关该主题的可用证据。搜索数据库（例如PubMed，EMBASE，Web of Science，MEDLINE和Cochrane图书馆）以研究从开始到2017年10月的这些关联为重点。使用以下任一方法计算汇总奇数比（OR）和95％置信区间（CI）根据研究之间的异质性建立随机或固定效应模型。还进行了亚组分析。总共确定了11个研究，包括530,176名参与者。在所有研究的汇总分析中，谷物暴露与GC风险无关（OR，1.11，95％CI，0.85-1.36）。具体分析表明，全谷物消耗与降低GC风险有关（OR，0.61，95％CI，0.40-0.83），精炼谷物消耗与升高GC风险有关（OR，1.65，95％CI，1.36-1.44）。 。较高的全谷物和较低的精炼谷物摄入量（而不是谷物消耗量）可以降低GC风险。该研究已在ClinicalTrials.gov（ID：NCT03419663）上注册。

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