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首页> 外文期刊>Food Science & Nutrition >Development and evaluation of floating alginate microspheres for oral delivery of anthocyanins ?￠???? A preliminary investigation
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Development and evaluation of floating alginate microspheres for oral delivery of anthocyanins ?￠???? A preliminary investigation

机译：开发和评估用于口服花色苷的漂浮藻酸盐微球的制备和评价初步调查

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Abstract The goal of this study was to develop floating microspheres that could be used as gastroretentive systems for the delivery of anthocyanins (ACNs). These compounds are absorbed in the stomach and small intestine, and insufficient residence time in these organs could result in limited absorption and contribute to degradation. The microparticles containing freeze-dried haskap berry extract (321.96 ???± 8.35 mg cyanidin 3-glucoside equivalents per g) were prepared by ionotropic gelation of alginate (9%, w/w) with calcium ions (CaCl 2 at 2%, w/v) in the gelation bath, with calcium carbonate as the gas-generating compound (added at different ratios in the alginate/extract mixture). The effect of acetic acid concentration (2 and 10%, v/v) in the gelation medium was investigated. Increasing the carbonate : alginate weigh ratio from 0 to 3:4 resulted in different degrees of floatability, larger particles, higher encapsulation efficiency, and lower amount of ACN released. The power law equation fitted the experimental data well, indicating that release occurred mainly by diffusion. This is the first time floating microspheres are proposed as gastroretentive platforms for the delivery of ACNs.
机译：摘要这项研究的目的是开发可以用作花色素苷（ACN）传递的胃滞留系统的漂浮微球。这些化合物在胃和小肠中被吸收，在这些器官中的停留时间不足会导致吸收受限，并导致降解。通过藻酸盐（9％，w / w）与钙离子（CaCl 2为2％，离子交换胶凝）制得含有冷冻干燥的哈斯卡普浆果提取物（321.96±8.35mg的花青素3-葡萄糖苷当量）的微粒。 （w / v）在凝胶浴中，用碳酸钙作为生成气体的化合物（以不同比例添加到藻酸盐/提取液混合物中）。研究了凝胶介质中乙酸浓度（2和10％，v / v）的影响。将碳酸盐：藻酸盐的重量比从0增加到3：4会导致不同程度的漂浮性，更大的颗粒，更高的包封效率和更少的ACN释放量。幂律方程很好地拟合了实验数据，表明释放主要通过扩散发生。这是首次提出将浮动微球用作递送ACN的胃滞留平台。

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