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首页> 外文期刊>Foods >Mechanisms of Antimicrobial Action of Cinnamon and Oregano Oils, Cinnamaldehyde, Carvacrol, 2,5-Dihydroxybenzaldehyde, and 2-Hydroxy-5-Methoxybenzaldehyde against Mycobacterium avium subsp. paratuberculosis ( Map )
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Mechanisms of Antimicrobial Action of Cinnamon and Oregano Oils, Cinnamaldehyde, Carvacrol, 2,5-Dihydroxybenzaldehyde, and 2-Hydroxy-5-Methoxybenzaldehyde against Mycobacterium avium subsp. paratuberculosis ( Map )

机译：肉桂和牛至油，肉桂醛，香芹酚，2,5-二羟基苯甲醛和2-羟基-5-甲氧基苯甲醛对鸟分枝杆菌亚种的抗菌作用机理。副结核病（地图）

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摘要

The antimicrobial modes of action of six naturally occurring compounds, cinnamon oil, cinnamaldehyde, oregano oil, carvacrol, 2,5-dihydroxybenzaldehyde, and 2-hydroxy-5-methoxybenzaldehyde, previously found to inhibit the growth of Mycobacterium avium subsp. paratuberculosis ( Map ) reported to infect food animals and humans and to be present in milk, cheese, and meat, were investigated. The incubation of Map cultures in the presence of all six compounds caused phosphate ions to leak into the extracellular environment in a time- and concentration-dependent manner. Cinnamon oil and cinnamaldehyde decreased the intracellular adenosine triphosphate (ATP) concentration of Map cells, whereas oregano oil and carvacrol caused an initial decrease of intracellular ATP concentration that was restored gradually after incubation at 37 °C for 2 h. Neither 2,5-dihydroxybenzaldehyde nor 2-hydroxy-5-methoxybenzaldehyde had a significant effect on intracellular ATP concentration. None of the compounds tested were found to cause leakage of ATP to the extracellular environment. Monolayer studies involving a Langmuir trough apparatus revealed that all anti- Map compounds, especially the essential oil compounds, altered the molecular packing characteristics of phospholipid molecules of model membranes, causing fluidization. The results of the physicochemical model microbial membrane studies suggest that the destruction of the pathogenic bacteria might be associated with the disruption of the bacterial cell membrane.
机译：六种天然存在的化合物（肉桂油，肉桂醛，牛至油，香芹酚，2,5-二羟基苯甲醛和2-羟基-5-甲氧基苯甲醛）的抗菌作用模式先前已发现可抑制鸟分枝杆菌亚种的生长。据报道，副结核病（Map）会感染食用动物和人类，并存在于牛奶，奶酪和肉中。在所有6种化合物的存在下孵育Map培养物会导致磷酸根离子以时间和浓度依赖的方式泄漏到细胞外环境中。肉桂油和肉桂醛降低了Map细胞的细胞内三磷酸腺苷（ATP）浓度，而牛至油和香芹酚导致细胞内ATP浓度初步降低，并在37°C孵育2小时后逐渐恢复。 2,5-二羟基苯甲醛和2-羟基-5-甲氧基苯甲醛均未对细胞内ATP浓度产生显着影响。没有发现所测试的化合物引起ATP泄漏到细胞外环境。涉及Langmuir槽装置的单层研究表明，所有抗Map化合物，尤其是精油化合物，都会改变模型膜磷脂分子的分子堆积特性，从而引起流态化。理化模型微生物膜研究的结果表明，致病细菌的破坏可能与细菌细胞膜的破坏有关。

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