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首页> 外文期刊>Food Science & Nutrition >Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice
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Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

机译：三重发酵大麦提取物（FBe）对HCl / EtOH诱导的小鼠胃黏膜损伤的保护作用

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摘要

This study was designed to observe the possible protective effects of a triple‐fermented barley ( Hordeum vulgare L.) extract (FBe) obtained by saccharification and using Saccharomyces cerevisiae and Weissella cibaria in alleviating gastric damage induced by a hydrochloric acid (HCl) and ethanol (EtOH) mixture in mice. After oral administration of FBe (300, 200, and 100?mg/kg) followed by 1?hr before and after the single treatment of HCl/EtOH (H/E) mixture, the hemorrhagic lesion scores, histopathology of the stomach, gastric nitrateitrite content, lipid peroxidation, and antioxidant defense systems including catalase and superoxide dismutase activities were observed. Following a single oral treatment of H/E‐induced gastric damages as measured by hemorrhagic gross lesions and histopathological gastric, ulcerative lesions were significantly and dose‐dependently ( p ??0.01 or p ??0.05) inhibited in mice, when all three different doses of FBe were administered as compared to those in H/E control mice. In particular, FBe also increased gastric nitrateitrite content and strengthened the antioxidant defense, with a decrease in the level of gastric lipid peroxidation, but increased the activities of CAT and SOD. Moreover, the effects of FBe are comparable to that of ranitidine, a reference drug. The obtained results suggest that this fermented barley extract prevented mice from H/E‐induced gastric mucosal damages through the suppression of inflammatory responses and oxidative stress‐responsive free radicals. Thus, FBe can be useful to treat patients suffering from gastric mucosal disorders as a potent food supplement, and thereby, it would increase the necessity of application in the food industry.
机译：这项研究旨在观察通过糖化获得的三发酵大麦（Hordeum vulgare L.）提取物（FBe）的可能保护作用，并使用酿酒酵母和Weissella cibaria减轻由盐酸（HCl）和乙醇引起的胃损伤（EtOH）小鼠混合物。口服FBe（300、200和100？mg / kg），然后在HCl / EtOH（H / E）混合物单次治疗前后1小时，出血性病变评分，胃，胃的组织病理学观察到硝酸盐/亚硝酸盐含量，脂质过氧化和抗氧化防御系统（包括过氧化氢酶和超氧化物歧化酶活性）。在一次口服治疗后，通过出血性总病变和组织病理学胃测量H / E引起的胃损害，在小鼠中，溃疡性病变被显着且剂量依赖性地抑制（p≤0.01或p≤0.05）。与H / E对照小鼠相比，施用了三种不同剂量的FBe。特别是，FBe还增加了胃中硝酸盐/亚硝酸盐的含量，增强了抗氧化防御能力，降低了胃脂质过氧化的水平，但增加了CAT和SOD的活性。此外，FBe的作用与雷尼替丁（一种参比药物）相当。获得的结果表明，这种发酵的大麦提取物可通过抑制炎症反应和氧化应激反应自由基来防止小鼠受到H / E诱导的胃粘膜损害。因此，FBe可以作为有效的食品补充剂用于治疗患有胃粘膜疾病的患者，因此，它将增加在食品工业中应用的必要性。

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