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首页> 外文期刊>Food Science & Nutrition >Delphinidin 3-rutinoside-rich blackcurrant extract ameliorates glucose tolerance by increasing the release of glucagon-like peptide-1 secretion
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Delphinidin 3-rutinoside-rich blackcurrant extract ameliorates glucose tolerance by increasing the release of glucagon-like peptide-1 secretion

机译：富含Delphinidin 3-rutinoside的黑加仑提取物通过增加胰高血糖素样肽1分泌的释放来改善葡萄糖耐量

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Abstract Glucagon-like peptide-1 (GLP-1) is an incretin that is secreted from enteroendocrine L-cells. Dietary factor-stimulation of endogenous GLP-1 is a promising strategy for increasing the action of GLP-1. Recent studies have shown that berries rich in anthocyanins improve insulin sensitivity and reduce the risk of type 2 diabetes. Our previous study found that the anthocyanin delphinidin 3-rutinoside (D3R) significantly increases GLP-1 secretion in GLUTag cells (enteroendocrine L cell line). Blackcurrants are berries that contain high levels of anthocyanins, particularly D3R. Pre-administered blackcurrant extract (BCE) 5 mg/kg body weight (1 mg D3R/kg) significantly ameliorated glucose tolerance after intraperitoneal glucose injection in rats by stimulating the secretion of GLP-1 and subsequently inducing insulin secretion. D3R did not break down significantly in the gastrointestinal tract for at least 45?￠????60 min after BCE was administered, suggesting that BCE-induced GLP-1 secretion is mainly mediated by D3R and not its degradation products. These findings demonstrate the novel biological function of D3R-rich BCE as a GLP-1 secretagogue. An increase in endogenous GLP-1 secretion induced by BCE may help to reduce the dosages of diabetic medicines and prevent diabetes.
机译：摘要胰高血糖素样肽1（GLP-1）是肠内分泌L细胞分泌的肠降血糖素。内源性GLP-1的饮食因素刺激是增加GLP-1作用的有前途的策略。最近的研究表明，富含花青素的浆果可提高胰岛素敏感性，并降低2型糖尿病的风险。我们先前的研究发现，花色苷delphinidin 3-rutinoside（D3R）显着增加了GLUTag细胞（内分泌L细胞系）中GLP-1的分泌。黑加仑是含有高水平花青素（尤其是D3R）的浆果。预先给予大鼠5 mg / kg体重（1 mg D3R / kg）的黑加仑提取物（BCE）通过刺激GLP-1的分泌并随后诱导胰岛素的分泌，可显着改善大鼠腹腔注射葡萄糖后的葡萄糖耐量。施用BCE后至少60分钟，D3R在胃肠道中没有明显分解，这表明BCE诱导的GLP-1分泌主要是由D3R而不是其降解产物介导的。这些发现证明了富含D3R的BCE作为GLP-1促分泌素的新型生物学功能。 BCE诱导的内源性GLP-1分泌增加可能有助于减少糖尿病药物的剂量并预防糖尿病。

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