• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Fisheries and Aquatic Sciences >Antibacterial Activity of an Ethyl Acetate Extract of Pseudomonas sp. UJ-6 against Methicillin-Resistant Staphylococcus aureus
【24h】

Antibacterial Activity of an Ethyl Acetate Extract of Pseudomonas sp. UJ-6 against Methicillin-Resistant Staphylococcus aureus

机译：假单胞菌菌种乙酸乙酯提取物的抗菌活性。 UJ-6抗耐甲氧西林金黄色葡萄球菌

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In an effort to discover an alternative antibiotic for treating infections with methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas sp. UJ-6, a marine bacterium that exhibited antibacterial activity against MRSA, was isolated. The culture broth and its ethyl acetate extract exhibited bactericidal activity against MRSA. The extract also exhibited antibacterial activity against gram-negative bacteria, which were not susceptible to vancomycin. The treatment of MRSA with the extract resulted in abnormal cell lysis. The extract retained >95% of its anti-MRSA activity after heat treatment for 15 min at . Thus, although most antibiotics are unstable under conditions of thermal stress, Pseudomonas sp. UJ-6 produces a heat-stable anti-MRSA substance. The results of this study strongly suggest that Pseudomonas sp. UJ-6 can be used to develop a novel, heat-stable, broad-spectrum antibiotic for the treatment of MRSA infections.
机译：为了发现一种替代抗生素，用于治疗耐甲氧西林的金黄色葡萄球菌（MRSA）感染，假单胞菌（Pseudomonas sp。）。分离出对MRSA表现出抗菌活性的海洋细菌UJ-6。培养液及其乙酸乙酯提取物表现出对MRSA的杀菌活性。该提取物还显示出对革兰氏阴性细菌的抗菌活性，该细菌对万古霉素不敏感。用提取物处理MRSA会导致细胞裂解异常。提取物在90℃下热处理15分钟后，其抗MRSA活性保持> 95％。因此，尽管大多数抗生素在热应激条件下不稳定，但假单胞菌属。 UJ-6产生热稳定的抗MRSA物质。这项研究的结果强烈建议假单胞菌属。 UJ-6可用于开发新颖的，热稳定的广谱抗生素，用于治疗MRSA感染。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号