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首页> 外文期刊>Frontiers in Microbiology >Antibiofilm and Antihyphal Activities of Cedar Leaf Essential Oil, Camphor, and Fenchone Derivatives against Candida albicans
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Antibiofilm and Antihyphal Activities of Cedar Leaf Essential Oil, Camphor, and Fenchone Derivatives against Candida albicans

机译：雪松叶香精油，樟脑和Fenchone衍生物对的抗菌膜和抗菌丝活性

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Candida albicans can form biofilms composed of yeast, hyphal, and pseudohyphal elements, and C. albicans cells in the hyphal stage could be a virulence factor. The present study describes the chemical composition, antibiofilm, and antihyphal activities of cedar leaf essential oil (CLEO), which was found to possess remarkable antibiofilm activity against C. albicans but not to affect its planktonic cell growth. Nineteen components were identified in CLEO by gas chromatography/mass spectrometry, and phenolics were the main constituents. Of these, camphor, fenchone, fenchyl alcohol, α-thujone, and borneol significantly reduced C. albicans biofilm formation. Notably, treatments with CLEO, camphor, or fenchyl alcohol at 0.01% clearly inhibited hyphal formation, and this inhibition appeared to be largely responsible for their antibiofilm effects. Transcriptomic analyses indicated that camphor and fenchyl alcohol downregulated some hypha-specific and biofilm related genes ( ECE1, ECE2, RBT1 , and EED1 ). Furthermore, camphor and fenchyl alcohol reduced C. albicans virulence in a Caenorhabditis elegans nematode model. These results demonstrate CLEO, camphor, and fenchyl alcohol might be useful for controlling C. albicans infections.
机译：白色念珠菌可以形成由酵母，菌丝和假菌丝元素组成的生物膜，菌丝阶段的白色念珠菌细胞可能是一种致病因子。本研究描述了雪松叶精油（CLEO）的化学成分，抗生物膜和抗菌丝活性，发现它们对白念珠菌具有显着的抗生物膜活性，但不影响其浮游细胞的生长。通过气相色谱/质谱法在CLEO中鉴定出19种成分，酚类是主要成分。其中，樟脑，fenchone，fenchyl醇，α-thujone和冰片可显着减少白色念珠菌生物膜的形成。值得注意的是，用0.01％的CLEO，樟脑或丁醇进行的处理明显抑制了菌丝的形成，而这种抑制作用似乎是其抗生物膜作用的主要原因。转录组学分析表明，樟脑和丁二醇下调了某些菌丝特异性和生物膜相关基因（ECE1，ECE2，RBT1和EED1）。此外，在秀丽隐杆线虫线虫模型中，樟脑和苯甲醇降低了白色念珠菌的毒力。这些结果表明，CLEO，樟脑和丁二醇可用于控制白色念珠菌感染。

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