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首页> 外文期刊>Frontiers in Immunology >Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis
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Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis

机译：Resolvin D2诱导解决根尖周炎并促进根尖周炎在大鼠根尖周炎中的愈合

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Periapical periodontitis results from pulpal infection leading to pulpal necrosis and resorption of periapical bone. The current treatment is root canal therapy, which attempts to eliminate infection and necrotic tissue. But, in some cases periapical inflammation doesn't resolve even after treatment. Resolvins belongs to a large family of specialized pro-resolving lipid mediators that actively resolves inflammation signaling via specific receptors. Resolvin D2 (RvD2), a metabolite of docosahexaenoic acid (DHA), was tested as an intracanal medicament in rats in vivo . Mechanism was evaluated in rat primary dental pulp cells (DPCs) in vitro . The results demonstrate that RvD2 reduces inflammatory cell infiltrate, periapical lesion size, and fosters pulp like tissue regeneration and healing of periapical lesion. RvD2 enhanced expression of its receptor, GPR18, dentin matrix acidic phosphoprotein 1 (DMP1) and mineralization in vivo and in vitro . Moreover, RvD2 induces phosphorylation of Stat3 transcription factor in dental pulp cells. We conclude that intracanal treatment with RvD2 resolves inflammation and promoting calcification around root apex and healing of periapical bone lesions. The data suggest that RvD2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions.
机译：根尖周炎是由牙髓感染导致的牙髓坏死和根尖周骨吸收所致。当前的治疗是根管治疗，其试图消除感染和坏死组织。但是，在某些情况下，即使经过治疗，根尖周炎症也无法解决。 Resolvins属于一大类特殊的亲分解脂质介体，可通过特定受体主动解决炎症信号传导。 Resolvin D2（RvD2）是二十二碳六烯酸（DHA）的代谢产物，已在体内作为大鼠的腔内药物进行了测试。在体外评价了大鼠原代牙髓细胞（DPC）的机制。结果表明RvD2减少炎症细胞浸润，根尖周病变的大小，并促进牙髓样组织再生和根尖周病变的愈合。 RvD2增强其受体GPR18，牙本质基质酸性磷酸蛋白1（DMP1）的表达以及体内和体外矿化作用。此外，RvD2诱导牙髓细胞中Stat3转录因子的磷酸化。我们得出的结论是，RvD2的管内治疗可解决炎症并促进根尖周围的钙化和根尖周骨病变的愈合。数据表明，RvD2在根管感染后通过牙髓样组织再生诱导炎症的主动消退，因此可能适合治疗根尖周病变。

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