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首页> 外文期刊>Frontiers in Neural Circuits >Developmental Changes in Electrophysiological Properties and a Transition from Electrical to Chemical Coupling between Excitatory Layer 4 Neurons in the Rat Barrel Cortex
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Developmental Changes in Electrophysiological Properties and a Transition from Electrical to Chemical Coupling between Excitatory Layer 4 Neurons in the Rat Barrel Cortex

机译：大鼠桶皮层兴奋性第4层神经元之间电生理特性的发展变化以及从电耦合到化学耦合的转变

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During development, sensory systems switch from an immature to an adult mode of function along with the emergence of the active cortical states. Here, we used patch-clamp recordings from neocortical slices in vitro to characterize the developmental changes in the basic electrophysiological properties of excitatory L4 neurons and their connectivity before and after the developmental switch, which occurs in the rat barrel cortex in vivo at postnatal day P8. Prior to the switch, L4 neurons had higher resting membrane potentials, higher input resistance, lower membrane capacity, as well as action potentials (APs) with smaller amplitudes, longer durations and higher AP thresholds compared to the neurons after the switch. A sustained firing pattern also emerged around the switch. Dual patch-clamp recordings from L4 neurons revealed that recurrent connections between L4 excitatory cells do not exist before and develop rapidly across the switch. In contrast, electrical coupling between these neurons waned around the switch. We suggest that maturation of electrophysiological features, particularly acquisition of a sustained firing pattern, and a transition from the immature electrical to mature chemical synaptic coupling between excitatory L4 neurons, contributes to the developmental switch in the cortical mode of function.
机译：在开发过程中，随着活跃的皮质状态的出现，感觉系统从不成熟的功能转变为成人的功能模式。在这里，我们使用了来自新皮层切片的膜片钳记录，以表征兴奋性L4神经元的基本电生理特性的发育变化及其在发育转换前后的连通性，这些变化发生在出生后第8天在大鼠体内的桶状皮层中。 。切换之前，与切换后的神经元相比，L4神经元具有更高的静息膜电位，更高的输入电阻，更低的膜容量以及具有较小幅度，更长持续时间和更高AP阈值的动作电位（AP）。开关周围也出现了持续的点火模式。 L4神经元的双重膜片钳录音显示，L4兴奋性细胞之间的复发性连接以前并不存在，并且在整个开关中迅速发展。相反，这些神经元之间的电耦合在开关周围减弱。我们建议，电生理特征的成熟，尤其是持续激发模式的获得，以及兴奋性L4神经元之间从不成熟的电突触到成熟化学突触耦合的过渡，有助于皮质功能模式的发育转换。

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